3a8n

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:15, 1 November 2023) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Crystal structure of the Tiam1 PHCCEx domain==
==Crystal structure of the Tiam1 PHCCEx domain==
-
<StructureSection load='3a8n' size='340' side='right' caption='[[3a8n]], [[Resolution|resolution]] 4.50&Aring;' scene=''>
+
<StructureSection load='3a8n' size='340' side='right'caption='[[3a8n]], [[Resolution|resolution]] 4.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3a8n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A8N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3A8N FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3a8n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A8N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A8N FirstGlance]. <br>
-
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3a8p|3a8p]], [[3a8q|3a8q]]</td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.5&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tiam1, Tiam-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a8n OCA], [https://pdbe.org/3a8n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a8n RCSB], [https://www.ebi.ac.uk/pdbsum/3a8n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a8n ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3a8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a8n OCA], [http://pdbe.org/3a8n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3a8n RCSB], [http://www.ebi.ac.uk/pdbsum/3a8n PDBsum]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/TIAM1_MOUSE TIAM1_MOUSE]] Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA (By similarity). Affects invasiveness of T-lymphoma cells.
+
[https://www.uniprot.org/uniprot/TIAM1_MOUSE TIAM1_MOUSE] Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA (By similarity). Affects invasiveness of T-lymphoma cells.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a8/3a8n_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a8/3a8n_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
Line 28: Line 28:
</div>
</div>
<div class="pdbe-citations 3a8n" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3a8n" style="background-color:#fffaf0;"></div>
- 
-
==See Also==
 
-
*[[Temperature color schemes|Temperature color schemes]]
 
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Lk3 transgenic mice]]
+
[[Category: Large Structures]]
-
[[Category: Hakoshima, T]]
+
[[Category: Mus musculus]]
-
[[Category: Higuchi, Y]]
+
[[Category: Hakoshima T]]
-
[[Category: Itoh, N]]
+
[[Category: Higuchi Y]]
-
[[Category: Kaibuchi, K]]
+
[[Category: Itoh N]]
-
[[Category: Kitano, K]]
+
[[Category: Kaibuchi K]]
-
[[Category: Mori, T]]
+
[[Category: Kitano K]]
-
[[Category: Terawaki, S]]
+
[[Category: Mori T]]
-
[[Category: Watanabe, T]]
+
[[Category: Terawaki S]]
-
[[Category: Zhai, Y]]
+
[[Category: Watanabe T]]
-
[[Category: Guanine nucleotide exchange factor]]
+
[[Category: Zhai Y]]
-
[[Category: Guanine-nucleotide releasing factor]]
+
-
[[Category: Lipoprotein]]
+
-
[[Category: Myristate]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Signaling protein]]
+

Current revision

Crystal structure of the Tiam1 PHCCEx domain

PDB ID 3a8n

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3a8n"
Personal tools