1kkd

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==Solution structure of the calmodulin binding domain (CaMBD) of small conductance Ca2+-activated potassium channels (SK2)==
==Solution structure of the calmodulin binding domain (CaMBD) of small conductance Ca2+-activated potassium channels (SK2)==
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<StructureSection load='1kkd' size='340' side='right' caption='[[1kkd]], [[NMR_Ensembles_of_Models | 23 NMR models]]' scene=''>
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<StructureSection load='1kkd' size='340' side='right'caption='[[1kkd]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1kkd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KKD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KKD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1kkd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KKD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KKD FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1g4y|1g4y]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SK2 (KCNN2) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kkd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kkd OCA], [https://pdbe.org/1kkd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kkd RCSB], [https://www.ebi.ac.uk/pdbsum/1kkd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kkd ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kkd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kkd OCA], [http://pdbe.org/1kkd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kkd RCSB], [http://www.ebi.ac.uk/pdbsum/1kkd PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KCNN2_RAT KCNN2_RAT]] Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.
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[https://www.uniprot.org/uniprot/KCNN2_RAT KCNN2_RAT] Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kk/1kkd_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kk/1kkd_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Potassium Channel|Potassium Channel]]
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*[[Potassium channel 3D structures|Potassium channel 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Buffalo rat]]
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[[Category: Large Structures]]
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[[Category: Adelman, J P]]
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[[Category: Rattus norvegicus]]
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[[Category: Bentrop, D]]
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[[Category: Adelman JP]]
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[[Category: Bildl, W]]
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[[Category: Bentrop D]]
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[[Category: Fakler, B]]
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[[Category: Bildl W]]
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[[Category: Kloecker, N]]
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[[Category: Fakler B]]
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[[Category: Neumann, H]]
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[[Category: Kloecker N]]
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[[Category: Rivard, A F]]
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[[Category: Neumann H]]
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[[Category: Schulte, U]]
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[[Category: Rivard AF]]
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[[Category: Weitz, D]]
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[[Category: Schulte U]]
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[[Category: Wissmann, R]]
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[[Category: Weitz D]]
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[[Category: Channel gating]]
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[[Category: Wissmann R]]
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[[Category: Signaling protein]]
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[[Category: Small-conductance calcium-activated potassium channel]]
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Current revision

Solution structure of the calmodulin binding domain (CaMBD) of small conductance Ca2+-activated potassium channels (SK2)

PDB ID 1kkd

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