This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4fiv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:50, 9 August 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
 +
==FIV PROTEASE COMPLEXED WITH AN INHIBITOR LP-130==
==FIV PROTEASE COMPLEXED WITH AN INHIBITOR LP-130==
-
<StructureSection load='4fiv' size='340' side='right' caption='[[4fiv]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
+
<StructureSection load='4fiv' size='340' side='right'caption='[[4fiv]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4fiv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Fiv Fiv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FIV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FIV FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4fiv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Feline_immunodeficiency_virus Feline immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FIV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FIV FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LP1:4-[2-(2-ACETYLAMINO-3-NAPHTALEN-1-YL-PROPIONYLAMINO)-4-METHYL-PENTANOYLAMINO]-3-HYDROXY-6-METHYL-HEPTANOIC+ACID+[1-(1-CARBAMOYL-2-NAPHTHALEN-1-YL-ETHYLCARBAMOYL)-PROPYL]-AMIDE'>LP1</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LP1:4-[2-(2-ACETYLAMINO-3-NAPHTALEN-1-YL-PROPIONYLAMINO)-4-METHYL-PENTANOYLAMINO]-3-HYDROXY-6-METHYL-HEPTANOIC+ACID+[1-(1-CARBAMOYL-2-NAPHTHALEN-1-YL-ETHYLCARBAMOYL)-PROPYL]-AMIDE'>LP1</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fiv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fiv OCA], [http://pdbe.org/4fiv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fiv RCSB], [http://www.ebi.ac.uk/pdbsum/4fiv PDBsum]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fiv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fiv OCA], [https://pdbe.org/4fiv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fiv RCSB], [https://www.ebi.ac.uk/pdbsum/4fiv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fiv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/POL_FIVPE POL_FIVPE]] During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.
+
[https://www.uniprot.org/uniprot/Q66972_9RETR Q66972_9RETR]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fi/4fiv_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fi/4fiv_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
Line 30: Line 31:
==See Also==
==See Also==
-
*[[Virus protease|Virus protease]]
+
*[[Immunodeficiency virus protease 3D structures|Immunodeficiency virus protease 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Fiv]]
+
[[Category: Feline immunodeficiency virus]]
-
[[Category: HIV-1 retropepsin]]
+
[[Category: Large Structures]]
-
[[Category: Gustchina, A]]
+
[[Category: Gustchina A]]
-
[[Category: Kervinen, J]]
+
[[Category: Kervinen J]]
-
[[Category: Lubkowski, J]]
+
[[Category: Lubkowski J]]
-
[[Category: Wlodawer, A]]
+
[[Category: Wlodawer A]]
-
[[Category: Zdanov, A]]
+
[[Category: Zdanov A]]
-
[[Category: Aspartic protease]]
+
-
[[Category: Cat]]
+
-
[[Category: Retropepsin]]
+
-
[[Category: Retrovirus]]
+

Current revision

FIV PROTEASE COMPLEXED WITH AN INHIBITOR LP-130

PDB ID 4fiv

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4fiv"
Personal tools