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2pt5

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==Crystal Structure Of Shikimate Kinase (aq_2177) From Aquifex Aeolicus vf5==
==Crystal Structure Of Shikimate Kinase (aq_2177) From Aquifex Aeolicus vf5==
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<StructureSection load='2pt5' size='340' side='right' caption='[[2pt5]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='2pt5' size='340' side='right'caption='[[2pt5]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2pt5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquae Aquae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PT5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PT5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2pt5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus_VF5 Aquifex aeolicus VF5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PT5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PT5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">aroK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224324 AQUAE])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pt5 OCA], [https://pdbe.org/2pt5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pt5 RCSB], [https://www.ebi.ac.uk/pdbsum/2pt5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pt5 ProSAT], [https://www.topsan.org/Proteins/RSGI/2pt5 TOPSAN]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Shikimate_kinase Shikimate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.71 2.7.1.71] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pt5 OCA], [http://pdbe.org/2pt5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pt5 RCSB], [http://www.ebi.ac.uk/pdbsum/2pt5 PDBsum], [http://www.topsan.org/Proteins/RSGI/2pt5 TOPSAN]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AROK_AQUAE AROK_AQUAE]] Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity).
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[https://www.uniprot.org/uniprot/AROK_AQUAE AROK_AQUAE] Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pt/2pt5_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pt/2pt5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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==See Also==
==See Also==
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*[[Shikimate kinase|Shikimate kinase]]
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*[[Shikimate kinase 3D structures|Shikimate kinase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Aquae]]
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[[Category: Aquifex aeolicus VF5]]
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[[Category: Shikimate kinase]]
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[[Category: Large Structures]]
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[[Category: Ebihara, A]]
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[[Category: Ebihara A]]
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[[Category: Jeyakanthan, J]]
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[[Category: Jeyakanthan J]]
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[[Category: Kuramitsu, S]]
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[[Category: Kuramitsu S]]
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[[Category: Nithya, N]]
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[[Category: Nithya N]]
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[[Category: Structural genomic]]
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[[Category: Shimada A]]
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[[Category: Shimada, A]]
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[[Category: Shinkai A]]
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[[Category: Shinkai, A]]
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[[Category: Shiro Y]]
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[[Category: Shiro, Y]]
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[[Category: Velmurugan D]]
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[[Category: Velmurugan, D]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S]]
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[[Category: Amino-acid biosynthesis]]
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[[Category: Aromatic amino acid biosynthesis]]
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[[Category: Atp-binding]]
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[[Category: Kinase]]
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[[Category: Magnesium]]
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[[Category: Metal-binding]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Nucleotide-binding]]
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[[Category: P-loop kinase]]
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[[Category: Rsgi]]
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[[Category: Shikimate pathway]]
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[[Category: Transferase]]
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Current revision

Crystal Structure Of Shikimate Kinase (aq_2177) From Aquifex Aeolicus vf5

PDB ID 2pt5

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