3fmg

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==Structure of rotavirus outer capsid protein VP7 trimer in complex with a neutralizing Fab==
==Structure of rotavirus outer capsid protein VP7 trimer in complex with a neutralizing Fab==
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<StructureSection load='3fmg' size='340' side='right' caption='[[3fmg]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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<StructureSection load='3fmg' size='340' side='right'caption='[[3fmg]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3fmg]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Simian_rotavirus Simian rotavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FMG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FMG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3fmg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Simian_rotavirus Simian rotavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FMG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FMG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">S9, VP7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10922 Simian rotavirus])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fmg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fmg OCA], [http://pdbe.org/3fmg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fmg RCSB], [http://www.ebi.ac.uk/pdbsum/3fmg PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fmg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fmg OCA], [https://pdbe.org/3fmg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fmg RCSB], [https://www.ebi.ac.uk/pdbsum/3fmg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fmg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/VP7_ROTRH VP7_ROTRH]] Outer capsid protein involved in attachment and possibly entry into the host epithelial cell. It is subsequently lost, together with VP4, following virus entry into the host cell. The outer layer contains 780 copies of VP7, grouped as 260 trimers. Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors. In integrin-dependent strains, VP7 seems to essentially target the integrin heterodimers ITGAX/ITGB2 and ITGA5/ITGB3 at a postbinding stage, once the initial attachment by VP4 has been achieved (By similarity).
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[https://www.uniprot.org/uniprot/VP7_ROTRH VP7_ROTRH] Outer capsid protein involved in attachment and possibly entry into the host epithelial cell. It is subsequently lost, together with VP4, following virus entry into the host cell. The outer layer contains 780 copies of VP7, grouped as 260 trimers. Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors. In integrin-dependent strains, VP7 seems to essentially target the integrin heterodimers ITGAX/ITGB2 and ITGA5/ITGB3 at a postbinding stage, once the initial attachment by VP4 has been achieved (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fm/3fmg_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fm/3fmg_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Antibody|Antibody]]
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*[[Antibody 3D structures|Antibody 3D structures]]
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*[[Monoclonal Antibody|Monoclonal Antibody]]
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*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
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*[[3D structures of non-human antibody|3D structures of non-human antibody]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Simian rotavirus]]
[[Category: Simian rotavirus]]
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[[Category: Aoki, S T]]
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[[Category: Aoki ST]]
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[[Category: Dormitzer, P R]]
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[[Category: Dormitzer PR]]
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[[Category: Greenberg, H B]]
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[[Category: Greenberg HB]]
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[[Category: Harrison, S C]]
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[[Category: Harrison SC]]
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[[Category: Settembre, E C]]
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[[Category: Settembre EC]]
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[[Category: Trask, S D]]
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[[Category: Trask SD]]
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[[Category: Alpha-beta-alpha sandwich]]
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[[Category: Antibody-antigen complex]]
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[[Category: Antiparallel beta-sandwich]]
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[[Category: Calcium dependent trimer]]
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[[Category: Capsid protein]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Glycoprotein]]
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[[Category: Immune system]]
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[[Category: Jelly roll]]
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[[Category: Membrane]]
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[[Category: Rossmann fold]]
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[[Category: Transmembrane]]
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[[Category: Virion]]
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Current revision

Structure of rotavirus outer capsid protein VP7 trimer in complex with a neutralizing Fab

PDB ID 3fmg

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