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3ffs

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==The Crystal Structure of Cryptosporidium parvum Inosine-5'-Monophosphate Dehydrogenase==
==The Crystal Structure of Cryptosporidium parvum Inosine-5'-Monophosphate Dehydrogenase==
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<StructureSection load='3ffs' size='340' side='right' caption='[[3ffs]], [[Resolution|resolution]] 3.19&Aring;' scene=''>
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<StructureSection load='3ffs' size='340' side='right'caption='[[3ffs]], [[Resolution|resolution]] 3.19&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ffs]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Crypv Crypv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FFS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ffs]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Cryptosporidium_parvum Cryptosporidium parvum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FFS FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IMPDH, 56k.02 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5807 CRYPV])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.19&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ffs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffs OCA], [https://pdbe.org/3ffs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ffs RCSB], [https://www.ebi.ac.uk/pdbsum/3ffs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ffs ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ffs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffs OCA], [http://pdbe.org/3ffs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ffs RCSB], [http://www.ebi.ac.uk/pdbsum/3ffs PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IMDH_CRYPV IMDH_CRYPV]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity).<ref>PMID:15269207</ref>
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[https://www.uniprot.org/uniprot/IMDH_CRYPV IMDH_CRYPV] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity).<ref>PMID:15269207</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ff/3ffs_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ff/3ffs_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Inosine monophosphate dehydrogenase|Inosine monophosphate dehydrogenase]]
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*[[Inosine monophosphate dehydrogenase 3D structures|Inosine monophosphate dehydrogenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Crypv]]
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[[Category: Cryptosporidium parvum]]
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[[Category: IMP dehydrogenase]]
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[[Category: Large Structures]]
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[[Category: Aquino, J A.D]]
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[[Category: D'Aquino JA]]
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[[Category: Hedstrom, L]]
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[[Category: Hedstrom L]]
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[[Category: Lu, J]]
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[[Category: Lu J]]
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[[Category: Petsko, G A]]
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[[Category: Petsko GA]]
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[[Category: Riera, T V]]
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[[Category: Riera TV]]
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[[Category: Beta-alpha barrel]]
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[[Category: Oxidoreductase]]
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[[Category: Tim fold]]
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Current revision

The Crystal Structure of Cryptosporidium parvum Inosine-5'-Monophosphate Dehydrogenase

PDB ID 3ffs

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