1fcn

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[[Image:1fcn.gif|left|200px]]
 
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{{Structure
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==Crystal Structure of the E. Coli AMPC Beta-Lactamase Mutant Q120L/Y150E Covalently Acylated with the Substrate Beta-Lactam LORACARBEF==
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|PDB= 1fcn |SIZE=350|CAPTION= <scene name='initialview01'>1fcn</scene>, resolution 2.35&Aring;
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<StructureSection load='1fcn' size='340' side='right'caption='[[1fcn]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=LOR:LORACABEF'>LOR</scene>
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<table><tr><td colspan='2'>[[1fcn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FCN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FCN FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LOR:LORACABEF+(OPEN+FORM)'>LOR</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fcn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fcn OCA], [https://pdbe.org/1fcn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fcn RCSB], [https://www.ebi.ac.uk/pdbsum/1fcn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fcn ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1fcm|1FCM]], [[1fco|1FCO]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fcn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fcn OCA], [http://www.ebi.ac.uk/pdbsum/1fcn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fcn RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/AMPC_ECOLI AMPC_ECOLI] This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fc/1fcn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fcn ConSurf].
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<div style="clear:both"></div>
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'''CRYSTAL STRUCTURE OF THE E. COLI AMPC BETA-LACTAMASE MUTANT Q120L/Y150E COVALENTLY ACYLATED WITH THE SUBSTRATE BETA-LACTAM LORACARBEF'''
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==See Also==
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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1FCN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FCN OCA].
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[[Category: Beta-lactamase]]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Blaszczak, L C.]]
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[[Category: Blaszczak LC]]
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[[Category: Patera, A.]]
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[[Category: Patera A]]
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[[Category: Shoichet, B K.]]
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[[Category: Shoichet BK]]
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[[Category: beta-lactamase beta-lactam complex]]
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[[Category: enzyme inhibitor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:20:19 2008''
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Current revision

Crystal Structure of the E. Coli AMPC Beta-Lactamase Mutant Q120L/Y150E Covalently Acylated with the Substrate Beta-Lactam LORACARBEF

PDB ID 1fcn

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