1fe6

[[Image:1fe6.jpg|left|200px]]

|PDB= 1fe6 |SIZE=350|CAPTION= <scene name='initialview01'>1fe6</scene>, resolution 1.80&Aring;

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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fe6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fe6 OCA], [http://www.ebi.ac.uk/pdbsum/1fe6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fe6 RCSB]</span>

 

 

 

The crystal structure of a polypeptide chain fragment from the surface layer protein tetrabrachion from Staphylothermus marinus has been determined at 1.8 A resolution. As proposed on the basis of the presence of 11-residue repeats, the polypeptide chain fragment forms a parallel right-handed coiled coil structure. Complementary hydrophobic interactions and complex networks of surface salt bridges result in an extremely thermostable tetrameric structure with remarkable properties. In marked contrast to left-handed coiled coil tetramers, the right-handed coiled coil reveals large hydrophobic cavities that are filled with water molecules. As a consequence, the packing of the hydrophobic core differs markedly from that of a right-handed parallel coiled coil tetramer that was designed on the basis of left-handed coiled coil structures.

 

1FE6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylothermus_marinus Staphylothermus marinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FE6 OCA].

 

==Reference==

Crystal structure of a naturally occurring parallel right-handed coiled coil tetramer., Stetefeld J, Jenny M, Schulthess T, Landwehr R, Engel J, Kammerer RA, Nat Struct Biol. 2000 Sep;7(9):772-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10966648 10966648]

[[Category: Single protein]]

[[Category: Stetefeld, J.]]