3fhp

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==A neutron crystallographic analysis of a porcine 2Zn insulin at 2.0 A resolution==
==A neutron crystallographic analysis of a porcine 2Zn insulin at 2.0 A resolution==
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<StructureSection load='3fhp' size='340' side='right' caption='[[3fhp]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='3fhp' size='340' side='right'caption='[[3fhp]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3fhp]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FHP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FHP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3fhp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FHP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FHP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Neutron Diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">INS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 PIG])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fhp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fhp OCA], [http://pdbe.org/3fhp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fhp RCSB], [http://www.ebi.ac.uk/pdbsum/3fhp PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fhp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fhp OCA], [https://pdbe.org/3fhp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fhp RCSB], [https://www.ebi.ac.uk/pdbsum/3fhp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fhp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/INS_PIG INS_PIG]] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
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[https://www.uniprot.org/uniprot/INS_PIG INS_PIG] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fh/3fhp_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fh/3fhp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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==See Also==
==See Also==
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*[[Molecular Playground/Insulin|Molecular Playground/Insulin]]
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*[[Insulin 3D Structures|Insulin 3D Structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Pig]]
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[[Category: Large Structures]]
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[[Category: Iwai, W]]
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[[Category: Sus scrofa]]
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[[Category: Kobayashi, Y]]
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[[Category: Iwai W]]
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[[Category: Kurihara, K]]
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[[Category: Kobayashi Y]]
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[[Category: Niimura, N]]
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[[Category: Kurihara K]]
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[[Category: Ohnishi, Y]]
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[[Category: Niimura N]]
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[[Category: Takahashi, H]]
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[[Category: Ohnishi Y]]
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[[Category: Tanaka, I]]
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[[Category: Takahashi H]]
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[[Category: Yamada, T]]
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[[Category: Tanaka I]]
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[[Category: 2zn insulin]]
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[[Category: Yamada T]]
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[[Category: Carbohydrate metabolism]]
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[[Category: Cleavage on pair of basic residue]]
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[[Category: Glucose metabolism]]
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[[Category: H/d exchange]]
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[[Category: Hormone]]
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[[Category: Neutron crystallography]]
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[[Category: Protonation]]
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[[Category: Secreted]]
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Current revision

A neutron crystallographic analysis of a porcine 2Zn insulin at 2.0 A resolution

PDB ID 3fhp

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