2jjp

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==Structure of cytochrome P450 EryK in complex with inhibitor ketoconazole (KC)==
==Structure of cytochrome P450 EryK in complex with inhibitor ketoconazole (KC)==
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<StructureSection load='2jjp' size='340' side='right' caption='[[2jjp]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='2jjp' size='340' side='right'caption='[[2jjp]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2jjp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_erythreus"_(sic)_waksman_1923 "actinomyces erythreus" (sic) waksman 1923]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JJP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2jjp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharopolyspora_erythraea Saccharopolyspora erythraea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JJP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=KLN:1-ACETYL-4-(4-{[(2S,4R)-2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL]METHOXY}PHENYL)PIPERAZINE'>KLN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2wio|2wio]], [[2vru|2vru]], [[2jjn|2jjn]], [[2vrv|2vrv]], [[2jjo|2jjo]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=KLN:1-ACETYL-4-(4-{[(2S,4R)-2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL]METHOXY}PHENYL)PIPERAZINE'>KLN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jjp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jjp OCA], [http://pdbe.org/2jjp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jjp RCSB], [http://www.ebi.ac.uk/pdbsum/2jjp PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jjp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jjp OCA], [https://pdbe.org/2jjp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jjp RCSB], [https://www.ebi.ac.uk/pdbsum/2jjp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jjp ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ERYK_SACEN ERYK_SACEN]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jj/2jjp_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jj/2jjp_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 2jjp" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2jjp" style="background-color:#fffaf0;"></div>
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==See Also==
 
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*[[Cytochrome P450|Cytochrome P450]]
 
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Kendrew, S G]]
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[[Category: Large Structures]]
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[[Category: Miele, A E]]
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[[Category: Saccharopolyspora erythraea]]
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[[Category: Savino, C]]
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[[Category: Kendrew SG]]
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[[Category: Sciara, G]]
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[[Category: Miele AE]]
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[[Category: Vallone, B]]
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[[Category: Savino C]]
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[[Category: Antibiotic biosynthesis]]
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[[Category: Sciara G]]
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[[Category: Heme]]
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[[Category: Vallone B]]
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[[Category: Iron]]
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[[Category: Metal-binding]]
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[[Category: Monooxygenase]]
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[[Category: Oxidoreductase]]
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[[Category: Substrate specificity]]
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[[Category: Tie-rod mechanism of action]]
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Current revision

Structure of cytochrome P450 EryK in complex with inhibitor ketoconazole (KC)

PDB ID 2jjp

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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