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1mr9

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==Crystal structure of Streptogramin A Acetyltransferase with acetyl-CoA bound==
==Crystal structure of Streptogramin A Acetyltransferase with acetyl-CoA bound==
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<StructureSection load='1mr9' size='340' side='right' caption='[[1mr9]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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<StructureSection load='1mr9' size='340' side='right'caption='[[1mr9]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1mr9]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_19434 Atcc 19434]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MR9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1mr9]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecium Enterococcus faecium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MR9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mr7|1mr7]], [[1mrl|1mrl]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mr9 OCA], [https://pdbe.org/1mr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mr9 RCSB], [https://www.ebi.ac.uk/pdbsum/1mr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mr9 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mr9 OCA], [http://pdbe.org/1mr9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mr9 RCSB], [http://www.ebi.ac.uk/pdbsum/1mr9 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/VATD_ENTFC VATD_ENTFC]] Inactivates the A compounds of streptogramin antibiotics by acetylation, thus providing resistance to these antibiotics.
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[https://www.uniprot.org/uniprot/VATD_ENTFC VATD_ENTFC] Inactivates the A compounds of streptogramin antibiotics by acetylation, thus providing resistance to these antibiotics.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mr/1mr9_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mr/1mr9_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 19434]]
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[[Category: Enterococcus faecium]]
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[[Category: Courvalin, P]]
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[[Category: Large Structures]]
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[[Category: Kehoe, L E]]
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[[Category: Courvalin P]]
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[[Category: Murray, I A]]
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[[Category: Kehoe LE]]
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[[Category: Rafferty, J B]]
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[[Category: Murray IA]]
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[[Category: Snidwongse, J]]
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[[Category: Rafferty JB]]
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[[Category: Left-handed parallel-beta helix domain]]
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[[Category: Snidwongse J]]
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[[Category: Transferase]]
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Current revision

Crystal structure of Streptogramin A Acetyltransferase with acetyl-CoA bound

PDB ID 1mr9

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