1fkh

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[[Image:1fkh.gif|left|200px]]
 
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{{Structure
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==DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS, AND THE X-RAY CRYSTAL STRUCTURES OF THEIR COMPLEXES WITH FKBP12==
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|PDB= 1fkh |SIZE=350|CAPTION= <scene name='initialview01'>1fkh</scene>, resolution 1.95&Aring;
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<StructureSection load='1fkh' size='340' side='right'caption='[[1fkh]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=SBX:1-CYCLOHEXYL-3-PHENYL-1-PROPYL-1-(3,3-DIMETHYL-1,2-DIOXYPENTYL)-2-PIPERIDINE+CARBOXYLATE'>SBX</scene>
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<table><tr><td colspan='2'>[[1fkh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FKH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FKH FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SBX:1-CYCLOHEXYL-3-PHENYL-1-PROPYL-1-(3,3-DIMETHYL-1,2-DIOXYPENTYL)-2-PIPERIDINE+CARBOXYLATE'>SBX</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fkh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fkh OCA], [https://pdbe.org/1fkh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fkh RCSB], [https://www.ebi.ac.uk/pdbsum/1fkh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fkh ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fkh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fkh OCA], [http://www.ebi.ac.uk/pdbsum/1fkh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fkh RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/FKB1A_HUMAN FKB1A_HUMAN] Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.<ref>PMID:9233797</ref> <ref>PMID:16720724</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fk/1fkh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fkh ConSurf].
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<div style="clear:both"></div>
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'''DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS, AND THE X-RAY CRYSTAL STRUCTURES OF THEIR COMPLEXES WITH FKBP12'''
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==See Also==
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*[[FKBP 3D structures|FKBP 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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1FKH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FKH OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bossard, M J.]]
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[[Category: Bossard MJ]]
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[[Category: Brandt, M.]]
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[[Category: Brandt M]]
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[[Category: Clardy, J.]]
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[[Category: Clardy J]]
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[[Category: Eggleston, D S.]]
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[[Category: Eggleston DS]]
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[[Category: Holt, D A.]]
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[[Category: Holt DA]]
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[[Category: Konialian, A L.]]
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[[Category: Konialian AL]]
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[[Category: Levy, M A.]]
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[[Category: Levy MA]]
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[[Category: Liang, J.]]
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[[Category: Liang J]]
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[[Category: Luengo, J I.]]
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[[Category: Luengo JI]]
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[[Category: Oh, H J.]]
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[[Category: Oh H-J]]
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[[Category: Rozamus, L W.]]
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[[Category: Rozamus LW]]
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[[Category: Schultz, L W.]]
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[[Category: Schultz LW]]
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[[Category: Stout, T J.]]
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[[Category: Stout TJ]]
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[[Category: Yamashita, D S.]]
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[[Category: Yamashita DS]]
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[[Category: Yen, H K.]]
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[[Category: Yen H-K]]
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[[Category: cis-trans isomerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:24:40 2008''
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Current revision

DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS, AND THE X-RAY CRYSTAL STRUCTURES OF THEIR COMPLEXES WITH FKBP12

PDB ID 1fkh

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