2ohv

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==Structural Basis for Glutamate Racemase Inhibition==
==Structural Basis for Glutamate Racemase Inhibition==
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<StructureSection load='2ohv' size='340' side='right' caption='[[2ohv]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='2ohv' size='340' side='right'caption='[[2ohv]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ohv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes_(serotype_1_/_m1_gas) Streptococcus pyogenes (serotype 1 / m1 gas)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OHV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OHV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2ohv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_M1_GAS Streptococcus pyogenes M1 GAS]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OHV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OHV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NHL:(4S)-4-(2-NAPHTHYLMETHYL)-D-GLUTAMIC+ACID'>NHL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1b73|1b73]], [[1zuw|1zuw]], [[2ohg|2ohg]], [[2oho|2oho]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NHL:(4S)-4-(2-NAPHTHYLMETHYL)-D-GLUTAMIC+ACID'>NHL</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">murI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=160490 Streptococcus pyogenes (serotype 1 / M1 GAS)])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ohv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ohv OCA], [https://pdbe.org/2ohv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ohv RCSB], [https://www.ebi.ac.uk/pdbsum/2ohv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ohv ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate_racemase Glutamate racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.3 5.1.1.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ohv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ohv OCA], [http://pdbe.org/2ohv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ohv RCSB], [http://www.ebi.ac.uk/pdbsum/2ohv PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MURI_STRP1 MURI_STRP1]] Provides the (R)-glutamate required for cell wall biosynthesis (By similarity).
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[https://www.uniprot.org/uniprot/MURI_STRP1 MURI_STRP1] Provides the (R)-glutamate required for cell wall biosynthesis (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oh/2ohv_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oh/2ohv_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Glutamate racemase|Glutamate racemase]]
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*[[Glutamate racemase 3D structures|Glutamate racemase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Glutamate racemase]]
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[[Category: Large Structures]]
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[[Category: Kim, E E]]
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[[Category: Streptococcus pyogenes M1 GAS]]
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[[Category: Isomerase]]
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[[Category: Kim EE]]
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[[Category: Racemase]]
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Current revision

Structural Basis for Glutamate Racemase Inhibition

PDB ID 2ohv

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