3hjn

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==Crystal structure of thymidylate kinase in complex with dTDP and ADP from Thermotoga maritima==
==Crystal structure of thymidylate kinase in complex with dTDP and ADP from Thermotoga maritima==
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<StructureSection load='3hjn' size='340' side='right' caption='[[3hjn]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='3hjn' size='340' side='right'caption='[[3hjn]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3hjn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thema Thema]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2z0h 2z0h]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HJN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HJN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3hjn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima_MSB8 Thermotoga maritima MSB8]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2z0h 2z0h]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HJN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HJN FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TYD:THYMIDINE-5-DIPHOSPHATE'>TYD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tmk, TM_1099 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243274 THEMA])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TYD:THYMIDINE-5-DIPHOSPHATE'>TYD</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hjn OCA], [https://pdbe.org/3hjn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hjn RCSB], [https://www.ebi.ac.uk/pdbsum/3hjn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hjn ProSAT], [https://www.topsan.org/Proteins/RSGI/3hjn TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hjn OCA], [http://pdbe.org/3hjn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hjn RCSB], [http://www.ebi.ac.uk/pdbsum/3hjn PDBsum], [http://www.topsan.org/Proteins/RSGI/3hjn TOPSAN]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KTHY_THEMA KTHY_THEMA]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hj/3hjn_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hj/3hjn_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Thymidylate kinase|Thymidylate kinase]]
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*[[Thymidylate kinase 3D structures|Thymidylate kinase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Thema]]
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[[Category: Large Structures]]
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[[Category: DTMP kinase]]
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[[Category: Thermotoga maritima MSB8]]
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[[Category: Kuramitsu, S]]
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[[Category: Kuramitsu S]]
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[[Category: Nakagawa, N]]
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[[Category: Nakagawa N]]
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[[Category: Structural genomic]]
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[[Category: Shirouzu M]]
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[[Category: Shirouzu, M]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S]]
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[[Category: Yoshikawa S]]
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[[Category: Yoshikawa, S]]
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[[Category: Atp-binding]]
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[[Category: Kinase]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Nucleotide biosynthesis]]
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[[Category: Nucleotide-binding]]
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[[Category: Rsgi]]
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[[Category: Thymidylate kinase]]
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[[Category: Transferase]]
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Current revision

Crystal structure of thymidylate kinase in complex with dTDP and ADP from Thermotoga maritima

PDB ID 3hjn

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