2o18
From Proteopedia
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==Crystal structure of a Thiamine biosynthesis lipoprotein apbE, NorthEast Strcutural Genomics target ER559== | ==Crystal structure of a Thiamine biosynthesis lipoprotein apbE, NorthEast Strcutural Genomics target ER559== | ||
| - | <StructureSection load='2o18' size='340' side='right' caption='[[2o18]], [[Resolution|resolution]] 2.20Å' scene=''> | + | <StructureSection load='2o18' size='340' side='right'caption='[[2o18]], [[Resolution|resolution]] 2.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2o18]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2o18]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O18 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O18 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o18 OCA], [https://pdbe.org/2o18 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o18 RCSB], [https://www.ebi.ac.uk/pdbsum/2o18 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o18 ProSAT], [https://www.topsan.org/Proteins/NESGC/2o18 TOPSAN]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/APBE_ECOLI APBE_ECOLI] Involved in the conversion of aminoimidazole ribotide (AIR), a purine intermediate, to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine (HMP) moiety of thiamine (By similarity). |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o1/2o18_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o1/2o18_consurf.spt"</scriptWhenChecked> |
| - | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> |
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Escherichia coli]] |
| - | [[Category: Acton | + | [[Category: Large Structures]] |
| - | [[Category: Baran | + | [[Category: Acton TB]] |
| - | [[Category: Cunningham | + | [[Category: Baran MC]] |
| - | [[Category: Fang | + | [[Category: Cunningham K]] |
| - | [[Category: Hunt | + | [[Category: Fang Y]] |
| - | [[Category: Liu | + | [[Category: Hunt JF]] |
| - | [[Category: Ma | + | [[Category: Liu J]] |
| - | [[Category: Montelione | + | [[Category: Ma L]] |
| - | + | [[Category: Montelione GT]] | |
| - | [[Category: Rost | + | [[Category: Rost B]] |
| - | [[Category: Seetharaman | + | [[Category: Seetharaman J]] |
| - | [[Category: Su | + | [[Category: Su M]] |
| - | [[Category: Tong | + | [[Category: Tong L]] |
| - | [[Category: Wang | + | [[Category: Wang D]] |
| - | [[Category: Xiao | + | [[Category: Xiao R]] |
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Current revision
Crystal structure of a Thiamine biosynthesis lipoprotein apbE, NorthEast Strcutural Genomics target ER559
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Categories: Escherichia coli | Large Structures | Acton TB | Baran MC | Cunningham K | Fang Y | Hunt JF | Liu J | Ma L | Montelione GT | Rost B | Seetharaman J | Su M | Tong L | Wang D | Xiao R
