2dky

From Proteopedia

(Difference between revisions)

Current revision

Solution structure of the SAM-domain of Rho-GTPase-activating protein 7

Structural highlights

2dky is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

RHG07_HUMAN Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.^[1] ^[2] ^[3]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Kim TY, Healy KD, Der CJ, Sciaky N, Bang YJ, Juliano RL. Effects of structure of Rho GTPase-activating protein DLC-1 on cell morphology and migration. J Biol Chem. 2008 Nov 21;283(47):32762-70. doi: 10.1074/jbc.M800617200. Epub 2008, Sep 11. PMID:18786931 doi:10.1074/jbc.M800617200
↑ Kawai K, Iwamae Y, Yamaga M, Kiyota M, Ishii H, Hirata H, Homma Y, Yagisawa H. Focal adhesion-localization of START-GAP1/DLC1 is essential for cell motility and morphology. Genes Cells. 2009 Feb;14(2):227-41. doi: 10.1111/j.1365-2443.2008.01265.x. Epub, 2008 Jan 15. PMID:19170769 doi:10.1111/j.1365-2443.2008.01265.x
↑ Erlmann P, Schmid S, Horenkamp FA, Geyer M, Pomorski TG, Olayioye MA. DLC1 activation requires lipid interaction through a polybasic region preceding the RhoGAP domain. Mol Biol Cell. 2009 Oct;20(20):4400-11. doi: 10.1091/mbc.E09-03-0247. Epub 2009, Aug 26. PMID:19710422 doi:10.1091/mbc.E09-03-0247

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2dky"

@@ Line 1: / Line 1: @@
 ==Solution structure of the SAM-domain of Rho-GTPase-activating protein 7==
-<StructureSection load='2dky' size='340' side='right' caption='[[2dky]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+<StructureSection load='2dky' size='340' side='right'caption='[[2dky]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2dky]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DKY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DKY FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2dky]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DKY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DKY FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DLC1, ARHGAP7, KIAA1723, STARD12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dky OCA], [http://pdbe.org/2dky PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dky RCSB], [http://www.ebi.ac.uk/pdbsum/2dky PDBsum], [http://www.topsan.org/Proteins/RSGI/2dky TOPSAN]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dky OCA], [https://pdbe.org/2dky PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dky RCSB], [https://www.ebi.ac.uk/pdbsum/2dky PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dky ProSAT], [https://www.topsan.org/Proteins/RSGI/2dky TOPSAN]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/RHG07_HUMAN RHG07_HUMAN]] Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.<ref>PMID:18786931</ref> <ref>PMID:19170769</ref> <ref>PMID:19710422</ref>
+[https://www.uniprot.org/uniprot/RHG07_HUMAN RHG07_HUMAN] Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.<ref>PMID:18786931</ref> <ref>PMID:19170769</ref> <ref>PMID:19710422</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
   <jmolCheckbox>
-    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dk/2dky_consurf.spt"</scriptWhenChecked>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dk/2dky_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
@@ Line 18: / Line 19: @@
 </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dky ConSurf].
 <div style="clear:both"></div>
+==See Also==
+*[[Rho GTPase activating protein 3D structures|Rho GTPase activating protein 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Goroncy, A K]]
+[[Category: Large Structures]]
-[[Category: Inoue, M]]
+[[Category: Goroncy AK]]
-[[Category: Kigawa, T]]
+[[Category: Inoue M]]
-[[Category: Koshiba, S]]
+[[Category: Kigawa T]]
-[[Category: Structural genomic]]
+[[Category: Koshiba S]]
-[[Category: Sato, M]]
+[[Category: Sato M]]
-[[Category: Yokoyama, S]]
+[[Category: Yokoyama S]]
-[[Category: Cell-free protein synthesis]]
-[[Category: National project on protein structural and functional analyse]]
-[[Category: Nppsfa]]
-[[Category: Protein regulation]]
-[[Category: Rsgi]]
-[[Category: Signaling protein]]

2dky

From Proteopedia

Current revision

Solution structure of the SAM-domain of Rho-GTPase-activating protein 7

Structural highlights

Function

Evolutionary Conservation

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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