1x4k

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==Solution structure of LIM domain in LIM-protein 3==
==Solution structure of LIM domain in LIM-protein 3==
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<StructureSection load='1x4k' size='340' side='right' caption='[[1x4k]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='1x4k' size='340' side='right'caption='[[1x4k]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1x4k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X4K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1X4K FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1x4k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X4K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X4K FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FHL2, DRAL, SLIM3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x4k OCA], [http://pdbe.org/1x4k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1x4k RCSB], [http://www.ebi.ac.uk/pdbsum/1x4k PDBsum], [http://www.topsan.org/Proteins/RSGI/1x4k TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x4k OCA], [https://pdbe.org/1x4k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x4k RCSB], [https://www.ebi.ac.uk/pdbsum/1x4k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x4k ProSAT], [https://www.topsan.org/Proteins/RSGI/1x4k TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FHL2_HUMAN FHL2_HUMAN]] May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation.<ref>PMID:15692560</ref> <ref>PMID:16652157</ref> <ref>PMID:18853468</ref>
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[https://www.uniprot.org/uniprot/FHL2_HUMAN FHL2_HUMAN] May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation.<ref>PMID:15692560</ref> <ref>PMID:16652157</ref> <ref>PMID:18853468</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x4/1x4k_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x4/1x4k_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: He, F]]
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[[Category: Large Structures]]
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[[Category: Inoue, M]]
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[[Category: He F]]
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[[Category: Kigawa, T]]
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[[Category: Inoue M]]
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[[Category: Muto, Y]]
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[[Category: Kigawa T]]
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[[Category: Structural genomic]]
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[[Category: Muto Y]]
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[[Category: Shirouzu, M]]
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[[Category: Shirouzu M]]
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[[Category: Terada, T]]
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[[Category: Terada T]]
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[[Category: Yokoyama, S]]
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[[Category: Yokoyama S]]
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[[Category: Lim domain]]
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[[Category: Metal binding protein]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Rsgi]]
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Current revision

Solution structure of LIM domain in LIM-protein 3

PDB ID 1x4k

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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