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1k1v

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==Solution Structure of the DNA-Binding Domain of MafG==
==Solution Structure of the DNA-Binding Domain of MafG==
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<StructureSection load='1k1v' size='340' side='right' caption='[[1k1v]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='1k1v' size='340' side='right'caption='[[1k1v]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1k1v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K1V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K1V FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1k1v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K1V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K1V FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k1v OCA], [http://pdbe.org/1k1v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1k1v RCSB], [http://www.ebi.ac.uk/pdbsum/1k1v PDBsum]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k1v OCA], [https://pdbe.org/1k1v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k1v RCSB], [https://www.ebi.ac.uk/pdbsum/1k1v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k1v ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MAFG_MOUSE MAFG_MOUSE]] Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF-E2. Activates globin gene expression when associated with NF-E2. May be involved in signal transduction of extracellular H(+) (By similarity).<ref>PMID:9679061</ref> <ref>PMID:16738329</ref>
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[https://www.uniprot.org/uniprot/MAFG_MOUSE MAFG_MOUSE] Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF-E2. Activates globin gene expression when associated with NF-E2. May be involved in signal transduction of extracellular H(+) (By similarity).<ref>PMID:9679061</ref> <ref>PMID:16738329</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k1/1k1v_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k1/1k1v_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Katsuoka, F]]
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[[Category: Mus musculus]]
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[[Category: Kusunoki, H]]
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[[Category: Katsuoka F]]
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[[Category: Morohashi, A]]
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[[Category: Kusunoki H]]
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[[Category: Motohashi, H]]
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[[Category: Morohashi A]]
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[[Category: Tanaka, T]]
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[[Category: Motohashi H]]
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[[Category: Yamamoto, M]]
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[[Category: Tanaka T]]
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[[Category: Dna binding protein]]
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[[Category: Yamamoto M]]
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[[Category: Dna-binding domain]]
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[[Category: Maf]]
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[[Category: Transcription factor]]
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Current revision

Solution Structure of the DNA-Binding Domain of MafG

PDB ID 1k1v

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