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3e0l

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==Computationally Designed Ammelide Deaminase==
==Computationally Designed Ammelide Deaminase==
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<StructureSection load='3e0l' size='340' side='right' caption='[[3e0l]], [[Resolution|resolution]] 2.37&Aring;' scene=''>
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<StructureSection load='3e0l' size='340' side='right'caption='[[3e0l]], [[Resolution|resolution]] 2.37&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3e0l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3E0L FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3e0l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E0L FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.37&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2uz9|2uz9]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GDA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e0l OCA], [https://pdbe.org/3e0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e0l RCSB], [https://www.ebi.ac.uk/pdbsum/3e0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e0l ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Guanine_deaminase Guanine deaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.4.3 3.5.4.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e0l OCA], [http://pdbe.org/3e0l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3e0l RCSB], [http://www.ebi.ac.uk/pdbsum/3e0l PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GUAD_HUMAN GUAD_HUMAN]] Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia (By similarity).
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[https://www.uniprot.org/uniprot/GUAD_HUMAN GUAD_HUMAN] Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e0/3e0l_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e0/3e0l_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Deaminase|Deaminase]]
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*[[Deaminase 3D structures|Deaminase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Guanine deaminase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Baker, D]]
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[[Category: Baker D]]
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[[Category: Bolduc, J M]]
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[[Category: Bolduc JM]]
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[[Category: Gallaher, J L]]
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[[Category: Gallaher JL]]
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[[Category: Murphy, P M]]
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[[Category: Murphy PM]]
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[[Category: Stoddard, B L]]
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[[Category: Stoddard BL]]
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[[Category: Computational-design backbone-flexibility loop-remodeling guanine cytosine ammelide deaminase]]
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[[Category: Hydrolase]]
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[[Category: Metal-binding]]
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Current revision

Computationally Designed Ammelide Deaminase

PDB ID 3e0l

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