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1f8t
From Proteopedia
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==FAB (LNKB-2) OF MONOCLONAL ANTIBODY, CRYSTAL STRUCTURE== | ==FAB (LNKB-2) OF MONOCLONAL ANTIBODY, CRYSTAL STRUCTURE== | ||
| - | <StructureSection load='1f8t' size='340' side='right' caption='[[1f8t]], [[Resolution|resolution]] 2.20Å' scene=''> | + | <StructureSection load='1f8t' size='340' side='right'caption='[[1f8t]], [[Resolution|resolution]] 2.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1f8t]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1f8t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F8T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F8T FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f8t OCA], [https://pdbe.org/1f8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f8t RCSB], [https://www.ebi.ac.uk/pdbsum/1f8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f8t ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
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Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f8/1f8t_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f8/1f8t_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f8t ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f8t ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | The three-dimensional structure of the antigen-binding fragment of a monoclonal antibody to human interleukin-2 was determined in two crystal forms by the X-ray method of molecular replacement at 2.2 and 2.9 A resolutions. The spatial structure of the protein and the stereochemistry of its antigen-binding site were analyzed. | ||
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| - | [Spatial structure of a Fab-fragment of a monoclonal antibody to human interleukin-2 in two crystalline forms at a resolution of 2.2 and 2.9 angstroms],Fokin AV, Afonin PV, Mikhailova IIu, Tsygannik IN, Mareeva TIu, Nesmeianov VA, Pangborn W, Lee N, Duax W, Siszak E, Pletnev VZ Bioorg Khim. 2000 Aug;26(8):571-8. PMID:11040993<ref>PMID:11040993</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 1f8t" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Monoclonal | + | *[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]] |
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Afonin | + | [[Category: Afonin PV]] |
| - | [[Category: Fokin | + | [[Category: Fokin AV]] |
| - | [[Category: Mareeva | + | [[Category: Mareeva TI]] |
| - | [[Category: Mikhailova | + | [[Category: Mikhailova II]] |
| - | [[Category: Tsygannik | + | [[Category: Tsygannik IN]] |
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Current revision
FAB (LNKB-2) OF MONOCLONAL ANTIBODY, CRYSTAL STRUCTURE
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