1ftn

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[[Image:1ftn.jpg|left|200px]]
 
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{{Structure
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==CRYSTAL STRUCTURE OF THE HUMAN RHOA/GDP COMPLEX==
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|PDB= 1ftn |SIZE=350|CAPTION= <scene name='initialview01'>1ftn</scene>, resolution 2.1&Aring;
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<StructureSection load='1ftn' size='340' side='right'caption='[[1ftn]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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<table><tr><td colspan='2'>[[1ftn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FTN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FTN FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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|GENE= SYNTHETIC HUMAN RHOA GENE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ftn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ftn OCA], [https://pdbe.org/1ftn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ftn RCSB], [https://www.ebi.ac.uk/pdbsum/1ftn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ftn ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ftn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ftn OCA], [http://www.ebi.ac.uk/pdbsum/1ftn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ftn RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/RHOA_HUMAN RHOA_HUMAN] Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.<ref>PMID:8910519</ref> <ref>PMID:9121475</ref> <ref>PMID:12900402</ref> <ref>PMID:16103226</ref> <ref>PMID:16236794</ref> <ref>PMID:19934221</ref> <ref>PMID:20937854</ref> <ref>PMID:20974804</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ft/1ftn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ftn ConSurf].
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<div style="clear:both"></div>
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'''CRYSTAL STRUCTURE OF THE HUMAN RHOA/GDP COMPLEX'''
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==See Also==
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*[[Rho GTPase 3D structures|Rho GTPase 3D structures]]
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== References ==
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==Overview==
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<references/>
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RhoA, a ubiquitous intracellular GTPase, mediates cytoskeletal responses to extracellular signals. A 2.1 A resolution crystal structure of the human RhoA-GDP complex shows unique stereochemistry in the switch I region, which results in a novel mode of Mg2+ binding.
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__TOC__
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</StructureSection>
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==About this Structure==
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1FTN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FTN OCA].
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==Reference==
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Crystal structure of RhoA-GDP and its functional implications., Wei Y, Zhang Y, Derewenda U, Liu X, Minor W, Nakamoto RK, Somlyo AV, Somlyo AP, Derewenda ZS, Nat Struct Biol. 1997 Sep;4(9):699-703. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9302995 9302995]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Derewenda, U.]]
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[[Category: Derewenda U]]
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[[Category: Derewenda, Z S.]]
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[[Category: Derewenda ZS]]
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[[Category: Liu, X.]]
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[[Category: Liu X]]
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[[Category: Minor, W.]]
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[[Category: Minor W]]
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[[Category: Nakamoto, R K.]]
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[[Category: Nakamoto RK]]
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[[Category: Somlyo, A P.]]
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[[Category: Somlyo AP]]
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[[Category: Somlyo, A V.]]
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[[Category: Somlyo AV]]
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[[Category: Wei, Y.]]
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[[Category: Wei Y]]
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[[Category: Zhang, Y.]]
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[[Category: Zhang Y]]
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[[Category: gtp-binding]]
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[[Category: lipoprotein]]
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[[Category: prenylation]]
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[[Category: proto-oncogene]]
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[[Category: small p-protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:30:08 2008''
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Current revision

CRYSTAL STRUCTURE OF THE HUMAN RHOA/GDP COMPLEX

PDB ID 1ftn

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