4pi3

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==Crystal structure analysis of cruzain bound to vinyl sulfone analog of WRR-483 (WRR-666)==
==Crystal structure analysis of cruzain bound to vinyl sulfone analog of WRR-483 (WRR-666)==
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<StructureSection load='4pi3' size='340' side='right' caption='[[4pi3]], [[Resolution|resolution]] 1.27&Aring;' scene=''>
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<StructureSection load='4pi3' size='340' side='right'caption='[[4pi3]], [[Resolution|resolution]] 1.27&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4pi3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PI3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PI3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4pi3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PI3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PI3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2V5:N-[(2S)-5-(CARBAMIMIDAMIDOOXY)-1-OXO-1-{[(1E,3S)-5-PHENYL-1-(PHENYLSULFONYL)PENT-1-EN-3-YL]AMINO}PENTAN-2-YL]-4-METHYLPIPERAZINE-1-CARBOXAMIDE'>2V5</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.27&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3lxs|3lxs]], [[2oz2|2oz2]], [[4xui|4xui]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2V5:N-[(2S)-5-(CARBAMIMIDAMIDOOXY)-1-OXO-1-{[(1E,3S)-5-PHENYL-1-(PHENYLSULFONYL)PENT-1-EN-3-YL]AMINO}PENTAN-2-YL]-4-METHYLPIPERAZINE-1-CARBOXAMIDE'>2V5</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cruzipain Cruzipain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.51 3.4.22.51] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pi3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pi3 OCA], [https://pdbe.org/4pi3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pi3 RCSB], [https://www.ebi.ac.uk/pdbsum/4pi3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pi3 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pi3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pi3 OCA], [http://pdbe.org/4pi3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pi3 RCSB], [http://www.ebi.ac.uk/pdbsum/4pi3 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CYSP_TRYCR CYSP_TRYCR]] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle.
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[https://www.uniprot.org/uniprot/CYSP_TRYCR CYSP_TRYCR] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4pi3" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4pi3" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Cruzain|Cruzain]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cruzipain]]
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[[Category: Large Structures]]
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[[Category: McKerrow, J H]]
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[[Category: Trypanosoma cruzi]]
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[[Category: Tochowicz, A]]
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[[Category: McKerrow JH]]
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[[Category: Analoge of wrr-483]]
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[[Category: Tochowicz A]]
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[[Category: Chagas disease]]
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[[Category: Covalent inhibitor]]
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[[Category: Cruzain]]
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[[Category: Cystein protease]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Vinyl sulfone derivative]]
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Current revision

Crystal structure analysis of cruzain bound to vinyl sulfone analog of WRR-483 (WRR-666)

PDB ID 4pi3

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