2nba

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'''Unreleased structure'''
 
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The entry 2nba is ON HOLD
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==Solution NMR structure of the minor DNA-uptake pilin ComP from Neisseri subflava==
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<StructureSection load='2nba' size='340' side='right'caption='[[2nba]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2nba]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_subflava_NJ9703 Neisseria subflava NJ9703]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NBA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NBA FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nba OCA], [https://pdbe.org/2nba PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nba RCSB], [https://www.ebi.ac.uk/pdbsum/2nba PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nba ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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DNA transformation is a widespread process allowing bacteria to capture free DNA by using filamentous nano-machines composed of type IV pilins. These proteins can act as DNA receptors as demonstrated by the finding that Neisseria meningitidis ComP minor pilin has intrinsic DNA-binding ability. ComP binds DNA better when it contains the DNA-uptake sequence (DUS) motif abundant in this species genome, playing a role in its trademark ability to selectively take up its own DNA. Here, we report high-resolution structures for meningococcal ComP and Neisseria subflava ComPsub, which recognize different DUS motifs. We show that they are structurally identical type IV pilins that pack readily into filament models and display a unique DD region delimited by two disulfide bonds. Functional analysis of ComPsub defines a new mode of DNA binding involving the DD region, adapted for exported DNA receptors.
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Authors: Berry, J.L., Xu, Y.
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A Comparative Structure/Function Analysis of Two Type IV Pilin DNA Receptors Defines a Novel Mode of DNA Binding.,Berry JL, Xu Y, Ward PN, Lea SM, Matthews SJ, Pelicic V Structure. 2016 May 3. pii: S0969-2126(16)30037-5. doi:, 10.1016/j.str.2016.04.001. PMID:27161979<ref>PMID:27161979</ref>
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Description: Solution NMR structure of the minor DNA-uptake pilin ComP from Neisseri subflava
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Xu, Y]]
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<div class="pdbe-citations 2nba" style="background-color:#fffaf0;"></div>
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[[Category: Berry, J.L]]
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==See Also==
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*[[Pilin 3D structures|Pilin 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Neisseria subflava NJ9703]]
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[[Category: Berry JL]]
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[[Category: Xu Y]]

Current revision

Solution NMR structure of the minor DNA-uptake pilin ComP from Neisseri subflava

PDB ID 2nba

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