1fue

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:19, 7 February 2024) (edit) (undo)
 
(15 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1fue.gif|left|200px]]
 
-
{{Structure
+
==FLAVODOXIN FROM HELICOBACTER PYLORI==
-
|PDB= 1fue |SIZE=350|CAPTION= <scene name='initialview01'>1fue</scene>, resolution 2.40&Aring;
+
<StructureSection load='1fue' size='340' side='right'caption='[[1fue]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>
+
<table><tr><td colspan='2'>[[1fue]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FUE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FUE FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-
|GENE=
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
-
|DOMAIN=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fue OCA], [https://pdbe.org/1fue PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fue RCSB], [https://www.ebi.ac.uk/pdbsum/1fue PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fue ProSAT]</span></td></tr>
-
|RELATEDENTRY=
+
</table>
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fue OCA], [http://www.ebi.ac.uk/pdbsum/1fue PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fue RCSB]</span>
+
== Function ==
-
}}
+
[https://www.uniprot.org/uniprot/FLAV_HELPJ FLAV_HELPJ] Low-potential electron donor to a number of redox enzymes (By similarity).
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fu/1fue_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fue ConSurf].
 +
<div style="clear:both"></div>
-
'''FLAVODOXIN FROM HELICOBACTER PYLORI'''
+
==See Also==
-
 
+
*[[Flavodoxin 3D structures|Flavodoxin 3D structures]]
-
 
+
__TOC__
-
==Overview==
+
</StructureSection>
-
The redox protein flavodoxin has been shown earlier to be reduced by the pyruvate-oxidoreductase (POR) enzyme complex of Helicobacter pylori, and also was proposed to be involved in the pathogenesis of gastric mucosa-associated lymphoid-tissue lymphoma (MALToma). Here, we report its X-ray structure, which is similar to flavodoxins of other bacteria and cyanobacteria. However, H. pylori flavodoxin has an alanine residue near the isoalloxazine ring of its cofactor flavin mononucleotide (FMN), while the other previously crystallized flavodoxins have a larger hydrophobic residue at this position. This creates a solute filled hole near the FMN cofactor of H. pylori flavodoxin. We also show that flavodoxin is essential for the survival of H. pylori, and conclude that its structure can be used as a starting point for the modeling of an inhibitor for the interaction between the POR-enzyme complex and flavodoxin.
+
-
 
+
-
==About this Structure==
+
-
1FUE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FUE OCA].
+
-
 
+
-
==Reference==
+
-
Crystal structure of oxidized flavodoxin, an essential protein in Helicobacter pylori., Freigang J, Diederichs K, Schafer KP, Welte W, Paul R, Protein Sci. 2002 Feb;11(2):253-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11790835 11790835]
+
[[Category: Helicobacter pylori]]
[[Category: Helicobacter pylori]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Diederichs, K.]]
+
[[Category: Diederichs K]]
-
[[Category: Freigang, J.]]
+
[[Category: Freigang J]]
-
[[Category: Paul, R.]]
+
[[Category: Paul R]]
-
[[Category: Schaefer, K P.]]
+
[[Category: Schaefer KP]]
-
[[Category: Welte, W.]]
+
[[Category: Welte W]]
-
[[Category: flavoprotein]]
+
-
[[Category: fmn]]
+
-
[[Category: helicobacter pylori]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:30:31 2008''
+

Current revision

FLAVODOXIN FROM HELICOBACTER PYLORI

PDB ID 1fue

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1fue"
Personal tools