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5eai
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of NAD(P)H dehydrogenase, quinone 1 complexed with a chemotherapeutic naphthoquinone E6a== | |
| - | + | <StructureSection load='5eai' size='340' side='right'caption='[[5eai]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5eai]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EAI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EAI FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E6A:(2~{R},3~{R})-2-[(2~{S},3~{S})-3-BROMANYL-1,4-BIS(OXIDANYLIDENE)-2,3-DIHYDRONAPHTHALEN-2-YL]-3-OXIDANYL-2,3-DIHYDRONAPHTHALENE-1,4-DIONE'>E6A</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5eai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eai OCA], [https://pdbe.org/5eai PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5eai RCSB], [https://www.ebi.ac.uk/pdbsum/5eai PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5eai ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/NQO1_HUMAN NQO1_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ahmad M]] | ||
| + | [[Category: Emadi A]] | ||
| + | [[Category: Mbimba JE]] | ||
| + | [[Category: Pidugu LS]] | ||
| + | [[Category: Pozharski E]] | ||
| + | [[Category: Sausville EA]] | ||
| + | [[Category: Toth EA]] | ||
Current revision
Crystal Structure of NAD(P)H dehydrogenase, quinone 1 complexed with a chemotherapeutic naphthoquinone E6a
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Categories: Homo sapiens | Large Structures | Ahmad M | Emadi A | Mbimba JE | Pidugu LS | Pozharski E | Sausville EA | Toth EA
