Erythropoietin receptor
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='' size='350' side='right' caption='2 extracellular domains of Human erythropoietin receptor (green) complex with erythropoietin (magenta) (PDB code [[1cn4]])' scene='70/705725/Cv/1'> |
== Function == | == Function == | ||
| - | '''Erythropoietin receptor''' (EpoR) is a cytokine receptor. Upon binding of erythropoietin (Epo), EpoR changes from a monomer to a dimer. | + | '''Erythropoietin receptor''' (EpoR) is a [[Cytokine receptors|cytokine receptor]]. Upon binding of erythropoietin (Epo), EpoR changes from a monomer to a dimer. This change induces the activation of Jak2 kinase via its autophosphorylation. Specific tyrosines in the intracellular part of EpoR are phosphorylated and activate various cascades of signal transduction which lead to the formation and maturation of red blood cells<ref>PMID:8481505</ref>. |
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| + | See also: [[Cytokine receptors]] and [[Immune receptors]] | ||
== Relevance == | == Relevance == | ||
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== Structural highlights == | == Structural highlights == | ||
| - | <scene name='70/705725/Cv/ | + | <scene name='70/705725/Cv/3'>Human erythropoietin receptor with erythropoietin</scene> (PDB code [[1cn4]]).<ref>PMID:9774108</ref> |
</StructureSection> | </StructureSection> | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | [[1ern]] – hEpoR extracellular domain - human <BR /> | + | [[1ern]] – hEpoR extracellular domain 25-249 - human <BR /> |
| - | [[2mv6]] – hEpoR transmembrane domain - NMR <BR /> | + | [[2mv6]] – hEpoR transmembrane domain 237-284 - NMR <BR /> |
[[1ebp]], [[1eba]] – hEpoR extracellular domain + Epo peptide <BR /> | [[1ebp]], [[1eba]] – hEpoR extracellular domain + Epo peptide <BR /> | ||
[[1cn4]], [[1eer]] – hEpoR extracellular domain (mutant) + Epo (mutant) <BR /> | [[1cn4]], [[1eer]] – hEpoR extracellular domain (mutant) + Epo (mutant) <BR /> | ||
| - | [[2jix]] – hEpoR extracellular domain + antibody <BR /> | + | [[2jix]], [[8vui]] – hEpoR extracellular domain + antibody <BR /> |
| - | [[4y5x]], [[4y5v]] – hEpoR extracellular domain + diabody <BR /> | + | [[8vvm]], [[8vvo]] – hEpoR extracellular domain (mutant) + antibody <BR /> |
| + | [[4y5x]], [[4y5v]], [[4y5y]] – hEpoR extracellular domain + diabody <BR /> | ||
| + | [[6moe]], [[6moh]], [[6moj]], [[6mof]], [[6moi]], [[6mok]], [[6mol]] – hEpoR extracellular domain + darpin <BR /> | ||
| + | [[6mol]], [[6e2q]] – hEpoR residues 273-338 + JAK2 <BR /> | ||
| + | [[2mxb]] – EpoR transmembrane domain – mouse - NMR <BR /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
| + | [[Category:Topic Page]] | ||
Current revision
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3D Structures of erythropoietin receptor
Updated on 03-June-2025
1ern – hEpoR extracellular domain 25-249 - human
2mv6 – hEpoR transmembrane domain 237-284 - NMR
1ebp, 1eba – hEpoR extracellular domain + Epo peptide
1cn4, 1eer – hEpoR extracellular domain (mutant) + Epo (mutant)
2jix, 8vui – hEpoR extracellular domain + antibody
8vvm, 8vvo – hEpoR extracellular domain (mutant) + antibody
4y5x, 4y5v, 4y5y – hEpoR extracellular domain + diabody
6moe, 6moh, 6moj, 6mof, 6moi, 6mok, 6mol – hEpoR extracellular domain + darpin
6mol, 6e2q – hEpoR residues 273-338 + JAK2
2mxb – EpoR transmembrane domain – mouse - NMR
References
- ↑ Youssoufian H, Longmore G, Neumann D, Yoshimura A, Lodish HF. Structure, function, and activation of the erythropoietin receptor. Blood. 1993 May 1;81(9):2223-36. PMID:8481505
- ↑ Syed RS, Reid SW, Li C, Cheetham JC, Aoki KH, Liu B, Zhan H, Osslund TD, Chirino AJ, Zhang J, Finer-Moore J, Elliott S, Sitney K, Katz BA, Matthews DJ, Wendoloski JJ, Egrie J, Stroud RM. Efficiency of signalling through cytokine receptors depends critically on receptor orientation. Nature. 1998 Oct 1;395(6701):511-6. PMID:9774108 doi:http://dx.doi.org/10.1038/26773
