5bw6

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==Tryptophan Synthase from Salmonella typhimurium in complex with a single molecule of 2-({[4-(trifluoromethoxy)phenyl]carbonyl}amino)ethyl dihydrogen phosphate (F6) in the alpha-site.==
==Tryptophan Synthase from Salmonella typhimurium in complex with a single molecule of 2-({[4-(trifluoromethoxy)phenyl]carbonyl}amino)ethyl dihydrogen phosphate (F6) in the alpha-site.==
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<StructureSection load='5bw6' size='340' side='right' caption='[[5bw6]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
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<StructureSection load='5bw6' size='340' side='right'caption='[[5bw6]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5bw6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BW6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5bw6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BW6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BW6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F6F:2-{[4-(TRIFLUOROMETHOXY)BENZOYL]AMINO}ETHYL+DIHYDROGEN+PHOSPHATE'>F6F</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wx2|4wx2]], [[4y6g|4y6g]], [[4zqc|4zqc]], [[2clm|2clm]], [[2cle|2cle]], [[2clf|2clf]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F6F:2-{[4-(TRIFLUOROMETHOXY)BENZOYL]AMINO}ETHYL+DIHYDROGEN+PHOSPHATE'>F6F</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan_synthase Tryptophan synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.20 4.2.1.20] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bw6 OCA], [https://pdbe.org/5bw6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bw6 RCSB], [https://www.ebi.ac.uk/pdbsum/5bw6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bw6 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bw6 OCA], [http://pdbe.org/5bw6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bw6 RCSB], [http://www.ebi.ac.uk/pdbsum/5bw6 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TRPA_SALTY TRPA_SALTY]] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. [[http://www.uniprot.org/uniprot/TRPB_SALTY TRPB_SALTY]] The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
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[https://www.uniprot.org/uniprot/TRPA_SALTY TRPA_SALTY] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5bw6" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5bw6" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Tryptophan synthase 3D structures|Tryptophan synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Tryptophan synthase]]
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[[Category: Large Structures]]
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[[Category: Caulkins, B G]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
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[[Category: Dunn, M F]]
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[[Category: Caulkins BG]]
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[[Category: Fan, L]]
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[[Category: Dunn MF]]
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[[Category: Hilario, E]]
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[[Category: Fan L]]
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[[Category: Mueller, L J]]
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[[Category: Hilario E]]
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[[Category: Niks, D]]
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[[Category: Mueller LJ]]
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[[Category: Young, R P]]
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[[Category: Niks D]]
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[[Category: Allosteric enzyme]]
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[[Category: Young RP]]
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[[Category: Aromatic amino acid biosynthesis]]
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[[Category: Carbon-oxygen lyase]]
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[[Category: F6f]]
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[[Category: Inhibitor]]
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[[Category: Lyase-lyase inhibitor complex]]
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[[Category: Pyridoxal phosphate]]
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[[Category: Salmonella typhimurium]]
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[[Category: Transferase]]
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[[Category: Tryptophan biosynthesis]]
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Current revision

Tryptophan Synthase from Salmonella typhimurium in complex with a single molecule of 2-({[4-(trifluoromethoxy)phenyl]carbonyl}amino)ethyl dihydrogen phosphate (F6) in the alpha-site.

PDB ID 5bw6

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OCA

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