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4z9v

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==TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL==
==TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL==
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<StructureSection load='4z9v' size='340' side='right' caption='[[4z9v]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='4z9v' size='340' side='right'caption='[[4z9v]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4z9v]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z9V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z9V FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4z9v]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z9V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Z9V FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.099&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z9v OCA], [http://pdbe.org/4z9v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z9v RCSB], [http://www.ebi.ac.uk/pdbsum/4z9v PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4z9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z9v OCA], [https://pdbe.org/4z9v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4z9v RCSB], [https://www.ebi.ac.uk/pdbsum/4z9v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4z9v ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> [[http://www.uniprot.org/uniprot/TCTP_HUMAN TCTP_HUMAN]] Involved in calcium binding and microtubule stabilization.
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[https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4z9v" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4z9v" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Agez, M]]
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[[Category: Homo sapiens]]
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[[Category: Cavarelli, J]]
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[[Category: Large Structures]]
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[[Category: Cura, V]]
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[[Category: Agez M]]
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[[Category: Thebault, S]]
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[[Category: Cavarelli J]]
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[[Category: Apoptose]]
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[[Category: Cura V]]
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[[Category: Apoptosis]]
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[[Category: Thebault S]]
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[[Category: Bh3]]
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[[Category: Tctp]]
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Current revision

TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL

PDB ID 4z9v

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