1fyg

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[[Image:1fyg.jpg|left|200px]]
 
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{{Structure
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==Solution structure of omega conotoxin SO3 determined by 1H-NMR==
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|PDB= 1fyg |SIZE=350|CAPTION= <scene name='initialview01'>1fyg</scene>
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<StructureSection load='1fyg' size='340' side='right'caption='[[1fyg]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1fyg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_striatus Conus striatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FYG FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fyg OCA], [https://pdbe.org/1fyg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fyg RCSB], [https://www.ebi.ac.uk/pdbsum/1fyg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fyg ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fyg OCA], [http://www.ebi.ac.uk/pdbsum/1fyg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fyg RCSB]</span>
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[https://www.uniprot.org/uniprot/O16O3_CONST O16O3_CONST] Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This peptide selectively targets Cav2.2/CACNA1B (IC(50)=160 nM) voltage-gated calcium channels (PubMed:26344359). When tested in mammals, this toxin displays an analgesic potency similar to MVIIA in a range of acute and chronic pain models in rodents, but has less adverse effects (tremor, diminution of spontaneous locomotor activity and bad coordinated locomotion) compared with identical dosages of MVIIA injected intrathecally.<ref>PMID:15880145</ref> <ref>PMID:26344359</ref>
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}}
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== References ==
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<references/>
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'''Solution structure of omega conotoxin SO3 determined by 1H-NMR'''
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__TOC__
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</StructureSection>
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[[Category: Conus striatus]]
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==About this Structure==
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[[Category: Large Structures]]
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1FYG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYG OCA].
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[[Category: Yan Y]]
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[[Category: Single protein]]
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[[Category: Zhang R]]
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[[Category: Yan, Y.]]
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[[Category: Zhang, R.]]
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[[Category: beta sheet]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:32:43 2008''
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Current revision

Solution structure of omega conotoxin SO3 determined by 1H-NMR

PDB ID 1fyg

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