Sandbox wabash15
From Proteopedia
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=="Structure of Trypsin"== | =="Structure of Trypsin"== | ||
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| - | + | By: Luke Knutson and Graham Redweik | |
| - | This is a sub structure of trypsin | + | This is a sub structure of trypsin '''Sandbox wabash15'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. |
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
| - | <scene name='Sandbox_45/Ctriadd102h57s195/4'>catalytic triad</scene> | + | <StructureSection load='2agg' size='340' side='right' caption='Acyl intermediate of trypsin catalyzed hydrolysis=''> |
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| + | *'''Trypsin''' is a serine protease formed in the small intestine and catalyzes the hydrolysis of smaller peptides. As with other members of its family, it possesses a <scene name='Sandbox_45/Ctriadd102h57s195/4'>catalytic triad</scene> (His-57, Asp-102, and Ser-195). This active site produces a nucleophilicity that enables its reaction with the serine groups on its substrate, i.e. smaller peptides. Within the catalytic triad-active site, an oxyanion hole exists that essentially stabilizes the acyl-intermediate states of the reaction, creating a binding pocket for the reaction to take place. These acyl-intermediates are key in protease reactions, as they are very susceptible to hydrolysis reactions, providing an opportunity for the second substrate of trypsin (water) to hydrolyze the interaction between His-57 and the attached C-terminus end of the protein substrate.. To stabilize this process, Asp-189 stabilizes the reaction by mediating an interaction with Lys or other positively-charged residues on the smaller protein. | ||
== Function == | == Function == | ||
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== Structural highlights == | == Structural highlights == | ||
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| - | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
<scene name='Sandbox_45/Btligand/1'>UB-THR 10</scene> | <scene name='Sandbox_45/Btligand/1'>UB-THR 10</scene> | ||
| - | </ | + | <scene name='Sandbox_45/Ctriadd102h57s195/4'>catalytic triad</scene> |
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| + | <scene name='Sandbox_45/Btsulfates/1'>sulfate ions</scene> | ||
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== References == | == References == | ||
<references/> | <references/> | ||
Current revision
"Structure of Trypsin"
By: Luke Knutson and Graham Redweik This is a sub structure of trypsin Sandbox wabash15. Click above on edit this page to modify. Be careful with the < and > signs. You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.
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