Epidermal growth factor
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
| - | All EGF family proteins contain a conserved amino acid sequence which includes <scene name='47/479230/Cv/ | + | All EGF family proteins contain a conserved amino acid sequence which includes <scene name='47/479230/Cv/3'>3 disulfide bonds</scene> (PDB code [[1jl9]]).<ref>PMID:11438527</ref> |
</StructureSection> | </StructureSection> | ||
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | *EGF | + | *EGF domains: extracellular 971-1023 |
| - | **[[1egf]], [[1epg]], [[1eph]], [[1epi]], [[1epj]], [[3egf]] – mEGF – mouse – NMR<br /> | ||
| - | **[[1a3p]] – mEGF (mutant) – NMR<br /> | ||
**[[1jl9]] – hEGF<br/ > | **[[1jl9]] – hEGF<br/ > | ||
**[[2kv4]] – hEGF - NMR<br/ > | **[[2kv4]] – hEGF - NMR<br/ > | ||
**[[1gk5]], [[1p9j]] – hEGF/transforming growth factor alpha - NMR<br /> | **[[1gk5]], [[1p9j]] – hEGF/transforming growth factor alpha - NMR<br /> | ||
| - | **[[1ivo]], [[1nql]], [[ | + | **[[1ivo]], [[3njp]] – hEGF 1-53 + EGFR<br /> |
| + | **[[1nql]] – hEGF extracellular domain + EGFR<br /> | ||
| + | **[[7syd]], [[7sye]], [[7sz0]], [[7sz1]], [[8hgs]] - hEGF extracellular domain + EGFR – Cryo EM<br /> | ||
| + | **[[8hgo]] – hEGF extracellular domain + HER2 + EGFR – Cryo EM<br /> | ||
| + | **[[7om4]] - hEGF extracellular domain + EGFR + nanobody<br /> | ||
| + | **[[1egf]], [[1epg]], [[1eph]], [[1epi]], [[1epj]], [[3egf]] – mEGF – mouse – NMR<br /> | ||
| + | **[[1a3p]] – mEGF (mutant) – NMR<br /> | ||
*Heparin-binding EGF-like growth factor | *Heparin-binding EGF-like growth factor | ||
Current revision
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3D structures of epidermal growth factor
Updated on 01-June-2025
References
- ↑ Carpenter G, Cohen S. Epidermal growth factor. J Biol Chem. 1990 May 15;265(14):7709-12. PMID:2186024
- ↑ Lu HS, Chai JJ, Li M, Huang BR, He CH, Bi RC. Crystal structure of human epidermal growth factor and its dimerization. J Biol Chem. 2001 Sep 14;276(37):34913-7. Epub 2001 Jul 3. PMID:11438527 doi:10.1074/jbc.M102874200
