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1zj0

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==Crystal Structure of Human Galactosyltransferase (GTB) Complexed with Lactose==
==Crystal Structure of Human Galactosyltransferase (GTB) Complexed with Lactose==
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<StructureSection load='1zj0' size='340' side='right' caption='[[1zj0]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
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<StructureSection load='1zj0' size='340' side='right'caption='[[1zj0]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1zj0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZJ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZJ0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1zj0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZJ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZJ0 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=LBT:ALPHA-LACTOSE'>LBT</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.67&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zhj|1zhj]], [[1zi1|1zi1]], [[1zi3|1zi3]], [[1zi4|1zi4]], [[1zi5|1zi5]], [[1ziz|1ziz]], [[1zjo|1zjo]], [[1zj1|1zj1]], [[1zj2|1zj2]], [[1zj3|1zj3]], [[1zjp|1zjp]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=PRD_900008:alpha-lactose'>PRD_900008</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zj0 OCA], [http://pdbe.org/1zj0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zj0 RCSB], [http://www.ebi.ac.uk/pdbsum/1zj0 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zj0 OCA], [https://pdbe.org/1zj0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zj0 RCSB], [https://www.ebi.ac.uk/pdbsum/1zj0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zj0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN]] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
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[https://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zj/1zj0_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zj/1zj0_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Glycosyltransferase|Glycosyltransferase]]
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*[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Barry, C H]]
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[[Category: Large Structures]]
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[[Category: Borisova, S N]]
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[[Category: Barry CH]]
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[[Category: Evans, S V]]
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[[Category: Borisova SN]]
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[[Category: Fang, Y R]]
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[[Category: Evans SV]]
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[[Category: Letts, J A]]
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[[Category: Fang YR]]
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[[Category: Palcic, M M]]
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[[Category: Letts JA]]
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[[Category: Rose, N L]]
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[[Category: Palcic MM]]
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[[Category: Seto, N O]]
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[[Category: Rose NL]]
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[[Category: Blood group]]
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[[Category: Seto NO]]
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[[Category: Gtb]]
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[[Category: H-antigen]]
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[[Category: Retaining]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of Human Galactosyltransferase (GTB) Complexed with Lactose

PDB ID 1zj0

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