5i2s
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5i2s is ON HOLD Authors: Roche, S., Bressanelli, S. Description: PREFUSION FORM OF THE VESICULAR STOMATITIS VIRUS GLYCOPROTEIN G ECTODOMAIN [[Categ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==PREFUSION FORM OF THE VESICULAR STOMATITIS VIRUS GLYCOPROTEIN G ECTODOMAIN== | |
| + | <StructureSection load='5i2s' size='340' side='right'caption='[[5i2s]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5i2s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vesicular_stomatitis_Indiana_virus_strain_Mudd-Summers Vesicular stomatitis Indiana virus strain Mudd-Summers]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2j6j 2j6j]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I2S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5I2S FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5i2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i2s OCA], [https://pdbe.org/5i2s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5i2s RCSB], [https://www.ebi.ac.uk/pdbsum/5i2s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5i2s ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/VGLG_VSIVM VGLG_VSIVM] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Glycoprotein G of the vesicular stomatitis virus triggers membrane fusion via a low pH-induced structural rearrangement. Despite the equilibrium between the pre- and postfusion states, the structure of the prefusion form, determined to 3.0 angstrom resolution, shows that the fusogenic transition entails an extensive structural reorganization of G. Comparison with the structure of the postfusion form suggests a pathway for the conformational change. In the prefusion form, G has the shape of a tripod with the fusion loops exposed, which point toward the viral membrane, and with the antigenic sites located at the distal end of the molecule. A large number of G glycoproteins, perhaps organized as in the crystals, act cooperatively to induce membrane merging. | ||
| - | + | Structure of the prefusion form of the vesicular stomatitis virus glycoprotein G.,Roche S, Rey FA, Gaudin Y, Bressanelli S Science. 2007 Feb 9;315(5813):843-8. PMID:17289996<ref>PMID:17289996</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: Bressanelli | + | <div class="pdbe-citations 5i2s" style="background-color:#fffaf0;"></div> |
| - | [[Category: Roche | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Vesicular stomatitis Indiana virus strain Mudd-Summers]] | ||
| + | [[Category: Bressanelli S]] | ||
| + | [[Category: Roche S]] | ||
Current revision
PREFUSION FORM OF THE VESICULAR STOMATITIS VIRUS GLYCOPROTEIN G ECTODOMAIN
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