5i3t

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m (Protected "5i3t" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5i3t is ON HOLD
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==Native Structure of the Linalool Dehydratase-Isomerase from Castellaniella defragrans==
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<StructureSection load='5i3t' size='340' side='right'caption='[[5i3t]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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Authors: LaMattina, J.W., Carlock, M., Koch, D.J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5i3t]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Castellaniella_defragrans Castellaniella defragrans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I3T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5I3T FirstGlance]. <br>
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Description: Native Structure of the Linalool Dehydratase-Isomerase from Castellaniella defragrans
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BU2:1,3-BUTANEDIOL'>BU2</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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[[Category: Koch, D.J]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5i3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i3t OCA], [https://pdbe.org/5i3t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5i3t RCSB], [https://www.ebi.ac.uk/pdbsum/5i3t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5i3t ProSAT]</span></td></tr>
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[[Category: Lamattina, J.W]]
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</table>
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[[Category: Carlock, M]]
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== Function ==
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[https://www.uniprot.org/uniprot/LDI_CASD6 LDI_CASD6] Anaerobically catalyzes the stereospecific hydration of beta-myrcene to (3S)-linalool and the isomerization of (3S)-linalool to geraniol (PubMed:20663876, PubMed:28068311, Ref.8). Is thus involved in the initial steps of the anaerobic degradation of the monoterpene beta-myrcene (PubMed:20663876). Also catalyzes the reverse reactions, i.e. the isomerization of geraniol to linalool and the dehydration of linalool to myrcene (PubMed:20663876, PubMed:28068311, Ref.8). In this direction, the formation of myrcene from geraniol may be seen as a detoxification process for the monoterpene alcohol (PubMed:20663876). Shows a relatively broad substrate specificity and can use various geraniol and linalool derivatives (PubMed:28068311). Substrates required a specific alpha-methylallyl alcohol signature motif (PubMed:28068311). Neither the monoterpenes alpha- and beta-ocimene nor the monoterpenoids citronellol and nerol can be used as substrates (PubMed:20663876).<ref>PMID:20663876</ref> <ref>PMID:28068311</ref> [REFERENCE:8]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Castellaniella defragrans]]
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[[Category: Large Structures]]
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[[Category: Carlock M]]
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[[Category: Koch DJ]]
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[[Category: LaMattina JW]]
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[[Category: Lanzilotta WN]]

Current revision

Native Structure of the Linalool Dehydratase-Isomerase from Castellaniella defragrans

PDB ID 5i3t

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