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Bone morphogenetic protein
From Proteopedia
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| - | <StructureSection load='2qja' size='350' side='right' caption='Human | + | <StructureSection load='2qja' size='350' side='right' caption='Human BMP-2 (grey and green) complex with BMP receptor extracellular domain (yellow and pink) (PDB entry [[2qja]])' scene=''> |
__TOC__ | __TOC__ | ||
== Function == | == Function == | ||
| - | '''Bone morphogenetic protein''' (BMP) are growth factors which can induce formation of bone and cartllage'<ref>PMID:19900831</ref>. Over 20 BMPs are known at present. BMP is part of the Transforming Growth Factor-β (TGF-β) family of proteins. For details on BMP- | + | '''Bone morphogenetic protein''' (BMP) are growth factors which can induce formation of bone and cartllage'<ref>PMID:19900831</ref>. Over 20 BMPs are known at present. BMP is part of the Transforming Growth Factor-β (TGF-β) family of proteins. |
| + | *'''BMP-1''' cleaves the C-propeptides of type I pro collagen during the synthesis of extracellular collagen fibrils<ref>PMID:12637537</ref>. | ||
| + | *'''BMP-2''' has important role in embryogenesis, bone formation and homeostasis<ref>PMID:32933207</ref>. | ||
| + | *'''BMP-3''' is a major component in osteogenin<ref>PMID:11263666</ref>. | ||
| + | *'''BMP-6''' is essential for expression of hepcidin which controls iron homeostasis<ref>PMID:34740612</ref>. | ||
| + | *'''BMP-7''' is a major role in embryogenesis, skeletal morphogenesis and neurogenesis<ref>PMID:31979268</ref>. For details on '''BMP-7''' see [[Student Projects for UMass Chemistry 423 Spring 2012-4]]. | ||
| + | *'''BMP-9''', '''BMP-11''' and '''Placental BMP-15''' see [[Growth differentiation factor]] | ||
| + | *'''BMP-10''' is cardiac-specific inducing trophoblast differentiation in stem cells<ref>PMID:24070570</ref>. | ||
| + | |||
| + | See also | ||
| + | *[[Growth factors]], | ||
| + | *[[Enzyme-linked receptor]] | ||
| + | *[[Growth differentiation factor]] | ||
| + | *[[TGF beta signaling pathway]]. | ||
== Relevance == | == Relevance == | ||
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BMP-7 is involved in chronic kidney disease<ref>PMID:18508541</ref>. | BMP-7 is involved in chronic kidney disease<ref>PMID:18508541</ref>. | ||
| - | == | + | ==3D structures of bone morphogenetic protein== |
| - | + | [[Bone morphogenetic protein 3D structures]] | |
</StructureSection> | </StructureSection> | ||
| - | ==3D structures of bone morphogenetic protein== | ||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | |||
| - | *Bone morphogenetic protein 1 | ||
| - | |||
| - | **[[3edg]], [[3edh]] – hBMP protease domain – human<br /> | ||
| - | |||
| - | *Bone morphogenetic protein 2 | ||
| - | |||
| - | **[[3bmp]] – hBMP <br /> | ||
| - | **[[1reu]] – hBMP (mutant)<br /> | ||
| - | **[[4n1d]] – hBMP/Nodal <br /> | ||
| - | **[[4mid]] – hBMP/activin A <br /> | ||
| - | **[[1es7]], [[1rew]], [[2qj9]], [[2qja]], [[2qjb]] – hBMP + BMP receptor IA<br /> | ||
| - | **[[3bk3]] – hBMP + crossveinless 2<br /> | ||
| - | **[[2goo]], [[2h62]], [[2h64]] – hBMP + BMP receptor IA + activin II receptor <br /> | ||
| - | **[[4uhy]], [[4uhz]], [[4ui0]], [[4ui1]] – hBMP C terminal + repulsive guidance molecule<br /> | ||
| - | **[[4ui2]] – hBMP C terminal + repulsive guidance molecule + neogenin<br /> | ||
| - | |||
| - | *Bone morphogenetic protein 3 | ||
| - | |||
| - | **[[2qcq]] – hBMP <br /> | ||
| - | |||
| - | *Bone morphogenetic protein 6 | ||
| - | |||
| - | **[[2qcw]], [[2r52]], [[2r53]] – hBMP <br /> | ||
| - | |||
| - | *Bone morphogenetic protein 7 | ||
| - | |||
| - | **[[1bmp]], [[1lxi]] – hBMP <br /> | ||
| - | **[[1m4u]] – hBMP + noggin<br /> | ||
| - | **[[1lx5]] – hBMP + activin II receptor<br /> | ||
| - | |||
| - | *Bone morphogenetic protein 9 | ||
| - | |||
| - | **[[1zkz]], [[4mpl]] – hBMP <br /> | ||
| - | **[[4ycg]], [[4yci]] – BMP - mouse<br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Reddi AH, Reddi A. Bone morphogenetic proteins (BMPs): from morphogens to metabologens. Cytokine Growth Factor Rev. 2009 Oct-Dec;20(5-6):341-2. doi:, 10.1016/j.cytogfr.2009.10.015. Epub 2009 Nov 8. PMID:19900831 doi:http://dx.doi.org/10.1016/j.cytogfr.2009.10.015
- ↑ Hartigan N, Garrigue-Antar L, Kadler KE. Bone morphogenetic protein-1 (BMP-1). Identification of the minimal domain structure for procollagen C-proteinase activity. J Biol Chem. 2003 May 16;278(20):18045-9. PMID:12637537 doi:10.1074/jbc.M211448200
- ↑ Halloran D, Durbano HW, Nohe A. Bone Morphogenetic Protein-2 in Development and Bone Homeostasis. J Dev Biol. 2020 Sep 13;8(3):19. PMID:32933207 doi:10.3390/jdb8030019
- ↑ Bahamonde ME, Lyons KM. BMP3: to be or not to be a BMP. J Bone Joint Surg Am. 2001;83-A Suppl 1(Pt 1):S56-62 PMID:11263666
- ↑ Wang S, Chen C, Yu L, Mueller J, Rausch V, Mueller S. Bone morphogenetic protein 6-mediated crosstalk between endothelial cells and hepatocytes recapitulates the iron-sensing pathway in vitro. J Biol Chem. 2021 Dec;297(6):101378. PMID:34740612 doi:10.1016/j.jbc.2021.101378
- ↑ Aluganti Narasimhulu C, Singla DK. The Role of Bone Morphogenetic Protein 7 (BMP-7) in Inflammation in Heart Diseases. Cells. 2020 Jan 23;9(2):280. PMID:31979268 doi:10.3390/cells9020280
- ↑ Lichtner B, Knaus P, Lehrach H, Adjaye J. BMP10 as a potent inducer of trophoblast differentiation in human embryonic and induced pluripotent stem cells. Biomaterials. 2013 Dec;34(38):9789-802. PMID:24070570 doi:10.1016/j.biomaterials.2013.08.084
- ↑ Mitu G, Hirschberg R. Bone morphogenetic protein-7 (BMP7) in chronic kidney disease. Front Biosci. 2008 May 1;13:4726-39. PMID:18508541
