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5fcg

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==Crystal structure of Bcl-2 in complex with HBx-BH3 motif==
==Crystal structure of Bcl-2 in complex with HBx-BH3 motif==
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<StructureSection load='5fcg' size='340' side='right' caption='[[5fcg]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='5fcg' size='340' side='right'caption='[[5fcg]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5fcg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FCG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FCG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5fcg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_B_virus Hepatitis B virus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FCG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FCG FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fcg OCA], [http://pdbe.org/5fcg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fcg RCSB], [http://www.ebi.ac.uk/pdbsum/5fcg PDBsum]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fcg OCA], [https://pdbe.org/5fcg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fcg RCSB], [https://www.ebi.ac.uk/pdbsum/5fcg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fcg ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN] Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/E9L5H4_HBV E9L5H4_HBV]] Multifunctional protein that may modulate protein degradation pathways, apoptosis, transcription, signal transduction, cell cycle progress, and genetic stability by directly or indirectly interacting with host factors.[RuleBase:RU361181]
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[https://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN] Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).<ref>PMID:18570871</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5fcg" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5fcg" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Jiang, T Y]]
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[[Category: Hepatitis B virus]]
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[[Category: Liu, M H]]
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[[Category: Homo sapiens]]
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[[Category: Shi, Y G]]
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[[Category: Large Structures]]
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[[Category: Wu, J P]]
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[[Category: Jiang TY]]
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[[Category: Apoptosis]]
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[[Category: Liu MH]]
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[[Category: Complex]]
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[[Category: Shi YG]]
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[[Category: Wu JP]]

Current revision

Crystal structure of Bcl-2 in complex with HBx-BH3 motif

PDB ID 5fcg

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