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4iyg

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==Structure of strictosidine synthase in complex with 2-(1H-INDOL-3-YL)-N-METHYLETHANAMINE==
==Structure of strictosidine synthase in complex with 2-(1H-INDOL-3-YL)-N-METHYLETHANAMINE==
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<StructureSection load='4iyg' size='340' side='right' caption='[[4iyg]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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<StructureSection load='4iyg' size='340' side='right'caption='[[4iyg]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4iyg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Devilpepper Devilpepper]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IYG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IYG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4iyg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rauvolfia_serpentina Rauvolfia serpentina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IYG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IYG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1HU:2-(1H-INDOL-3-YL)-N-METHYLETHANAMINE'>1HU</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.702&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">STR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4060 Devilpepper])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1HU:2-(1H-INDOL-3-YL)-N-METHYLETHANAMINE'>1HU</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Strictosidine_synthase Strictosidine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.2 4.3.3.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iyg OCA], [https://pdbe.org/4iyg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iyg RCSB], [https://www.ebi.ac.uk/pdbsum/4iyg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iyg ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iyg OCA], [http://pdbe.org/4iyg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4iyg RCSB], [http://www.ebi.ac.uk/pdbsum/4iyg PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/STSY_RAUSE STSY_RAUSE]] Catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis.
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[https://www.uniprot.org/uniprot/STSY_RAUSE STSY_RAUSE] Catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Devilpepper]]
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[[Category: Large Structures]]
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[[Category: Strictosidine synthase]]
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[[Category: Rauvolfia serpentina]]
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[[Category: Fangrui, W]]
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[[Category: Fangrui W]]
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[[Category: Rajendran, C]]
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[[Category: Rajendran C]]
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[[Category: Stoeckigt, J]]
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[[Category: Stoeckigt J]]
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[[Category: Wang, M]]
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[[Category: Wang M]]
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[[Category: Lyase-lyase inhibitor complex]]
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Current revision

Structure of strictosidine synthase in complex with 2-(1H-INDOL-3-YL)-N-METHYLETHANAMINE

PDB ID 4iyg

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