5i5o
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5i5o is ON HOLD Authors: Liu, Y., Liang, H., Yang, M. Description: Crystal Structure of N-terminal Domain of Matrix Protein of Thogoto Virus at Neu...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of N-terminal Domain of Matrix Protein of Thogoto Virus at Neutral pH.== | |
| + | <StructureSection load='5i5o' size='340' side='right'caption='[[5i5o]], [[Resolution|resolution]] 2.68Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5i5o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thogoto_thogotovirus Thogoto thogotovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I5O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5I5O FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.682Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5i5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i5o OCA], [https://pdbe.org/5i5o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5i5o RCSB], [https://www.ebi.ac.uk/pdbsum/5i5o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5i5o ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ML_THOGV ML_THOGV] Blocks host IRF3 and IRF7, thereby inhibiting IFN-beta expression and activation of host antiviral state.<ref>PMID:15582653</ref> <ref>PMID:18768974</ref> <ref>PMID:19812269</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The matrix proteins of orthomyxoviruses, including influenza virus, infectious salmon anemia virus and Thogoto virus, play crucial roles in essential processes of the viral life cycle. However, the mechanisms of the matrix proteins involved in these processes are not fully understood. Currently, only the structure and function of the matrix protein from influenza virus have been studied. Here, we present the crystal structures of the N-terminal domain of matrix protein from Thogoto virus at pH 7.0 and 4.5. By analyzing the structures, we identified the conformational changes of monomers and dimers in different pH conditions, mainly caused by two flexible loops, L3 and L5. We suggest these structural deviations would reflect the basis of viral capsid assembly or disassembly. | ||
| - | + | Conformational changes of matrix protein from Thogoto virus at different pH implicate the mechanism of viral assembly and uncoating.,Yang M, Feng F, Liu Y, Wang H, Yang Z, Hou W, Liang H J Gen Virol. 2016 Jul 13. doi: 10.1099/jgv.0.000551. PMID:27411929<ref>PMID:27411929</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 5i5o" style="background-color:#fffaf0;"></div> |
| - | [[Category: Liu | + | == References == |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Thogoto thogotovirus]] | ||
| + | [[Category: Liang H]] | ||
| + | [[Category: Liu Y]] | ||
| + | [[Category: Yang M]] | ||
Current revision
Crystal Structure of N-terminal Domain of Matrix Protein of Thogoto Virus at Neutral pH.
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