5ay7

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==A psychrophilic glycoside hydrolase family 10 endo-beta-1,4-xylanase==
==A psychrophilic glycoside hydrolase family 10 endo-beta-1,4-xylanase==
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<StructureSection load='5ay7' size='340' side='right' caption='[[5ay7]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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<StructureSection load='5ay7' size='340' side='right'caption='[[5ay7]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ay7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AY7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AY7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ay7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aegilops_speltoides_subsp._speltoides Aegilops speltoides subsp. speltoides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AY7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AY7 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5d4y|5d4y]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endo-1,4-beta-xylanase Endo-1,4-beta-xylanase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.8 3.2.1.8] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ay7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ay7 OCA], [https://pdbe.org/5ay7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ay7 RCSB], [https://www.ebi.ac.uk/pdbsum/5ay7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ay7 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ay7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ay7 OCA], [http://pdbe.org/5ay7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ay7 RCSB], [http://www.ebi.ac.uk/pdbsum/5ay7 PDBsum]</span></td></tr>
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</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/A0A140UHL2_AEGSP A0A140UHL2_AEGSP]
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The cold-adapted xylanases can catalyze at low temperature and hold great potential in food industry applications. Here we describe the first crystal structure of a cold-adapted glycoside hydrolase (GH) family 10 xylanase XynGR40 and its complex with xylobiose at 2.15 and 2.50A resolution. The enzyme folds into a typical GH10 (beta/alpha)8 TIM-barrel, with E132 and E243 serving as the catalytic residues. The xylobiose was observed to occupy the -1 and -2 subsites. Structural comparison with a thermophilic GH10 xylanase highlighting various parameters that may explain the cold adaptation features were analyzed. Synergistic effects of the increased exposure of hydrophobic residues, the higher flexibility of substrate-binding residues, more flexible loops, and the ratios of special amino acid residues, may result in the cold adaptation of XynGR40.
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Structural insight into potential cold adaptation mechanism through a psychrophilic glycoside hydrolase family 10 endo-beta-1,4-xylanase.,Zheng Y, Li Y, Liu W, Chen CC, Ko TP, He M, Xu Z, Liu M, Luo H, Guo RT, Yao B, Ma Y J Struct Biol. 2016 Mar;193(3):206-11. doi: 10.1016/j.jsb.2015.12.010. Epub 2015 , Dec 21. PMID:26719223<ref>PMID:26719223</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5ay7" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Endo-1,4-beta-xylanase]]
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[[Category: Aegilops speltoides subsp. speltoides]]
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[[Category: Guo, R T]]
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[[Category: Large Structures]]
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[[Category: Li, Y]]
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[[Category: Guo RT]]
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[[Category: Liu, W]]
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[[Category: Li Y]]
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[[Category: Zheng, Y]]
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[[Category: Liu W]]
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[[Category: Gh10]]
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[[Category: Zheng Y]]
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[[Category: Hydrolase]]
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[[Category: Tim-barrel fold]]
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[[Category: Xylanase]]
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Current revision

A psychrophilic glycoside hydrolase family 10 endo-beta-1,4-xylanase

PDB ID 5ay7

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