2nb4
From Proteopedia
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==Solution structure of Q388A3 PDZ domain== | ==Solution structure of Q388A3 PDZ domain== | ||
| - | <StructureSection load='2nb4' size='340' side='right' caption='[[2nb4 | + | <StructureSection load='2nb4' size='340' side='right'caption='[[2nb4]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2nb4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NB4 OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[2nb4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei_TREU927 Trypanosoma brucei brucei TREU927]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NB4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NB4 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nb4 OCA], [https://pdbe.org/2nb4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nb4 RCSB], [https://www.ebi.ac.uk/pdbsum/2nb4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nb4 ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q388A3_TRYB2 Q388A3_TRYB2] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | PDZ domains are abundant protein interaction modules that often recognize short amino acid motifs at the C-termini of target proteins and regulate multiple biological processes. So far, no PDZ domain in Trypanosoma brucei, an eukaryotic parasite causing sleeping sickness, has been studied. Q388A3, conserved in the related kinetoplastid parasites, is a 1634-residue protein containing a PDZ domain at its C-terminus. In this work, the solution structure of Q388A3 PDZ domain was solved by NMR spectroscopy. Q388A3 PDZ domain adopts a PDZ-like fold composed by a five-stranded beta-sheet capped by two alpha-helices, which is similar to the PDZ domains from HtrA family proteins. Meanwhile, Q388A3 PDZ domain shows some structural features quite different from HtrA PDZ domain. | ||
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| + | Solution structure of Q388A3 PDZ domain from Trypanosoma brucei.,Mei S, Dong Y, Zhang J, Zhang X, Tu X J Struct Biol. 2016 May;194(2):214-7. doi: 10.1016/j.jsb.2016.02.018. Epub 2016, Feb 22. PMID:26917351<ref>PMID:26917351</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 2nb4" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Trypanosoma brucei brucei TREU927]] |
| - | [[Category: | + | [[Category: Mei S]] |
Current revision
Solution structure of Q388A3 PDZ domain
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