Uracil glycosylase inhibitor

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:13, 7 January 2021) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
<StructureSection load='1uug' size='400' side='right' caption='Structure of uracil glycosylase inhibitor (green and yellow) complex with uracil DNA glycosylase (grey and pink) (PDB entry [[1uug]])' scene=''>
+
<StructureSection load='1uug' size='350' side='right' caption='Structure of uracil glycosylase inhibitor (green) complex with uracil DNA glycosylase (cyan) (PDB entry [[1uug]])' scene='51/516470/Cv/1'>
-
'''Uracil glycosylase inhibitor''' (UGI) is a small protein from Bacillus subtilis bacteriophage PBS1 which inhibits E. coli and other species’ uracil DNA glycosylase (UDG). UGI can disassociate UDG:DNA complexes.
+
== Function ==
 +
'''Uracil glycosylase inhibitor''' or '''uracil-DNA glycosylase inhibitor''' (UGI) is a small protein from ''Bacillus subtilis'' bacteriophage PBS1 which inhibits ''E. coli'' and other species’ uracil DNA glycosylase (UDG). UGI can disassociate UDG:DNA complexes<ref>PMID:12855717</ref>.
 +
 
 +
== Structural highlights ==
 +
The <scene name='51/516470/Cv/3'>surface interactions between the UDG and UGI is fairly polar</scene><ref>PMID:10080896</ref> ({{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}). Interacting UGI residues shown in ball-and-stick representation, UDG residues shown in spacefill representation.
==3D structures of uracil glycosylase inhibitor==
==3D structures of uracil glycosylase inhibitor==
 +
 +
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
[[1ugi]], [[2ugi]] – UGI<br />
[[1ugi]], [[2ugi]] – UGI<br />
Line 10: Line 16:
[[1udi]] – UGI + HsvUDG – Herpes simplex virus<br />
[[1udi]] – UGI + HsvUDG – Herpes simplex virus<br />
[[2j8x]] - UGI + EBvUDG – Epstein-Barr virus<br />
[[2j8x]] - UGI + EBvUDG – Epstein-Barr virus<br />
-
[[2zhx]] - UGI + MtUDG – ''Mycobacterium tuberculosis''
+
[[6lyd]], [[6lye]] - UGI + UDG – Bacillus phage PBS2<br />
 +
[[2zhx]] - UGI + MtUDG – ''Mycobacterium tuberculosis''<br />
 +
[[4lyl]] – UDI + UDG – atlantic cod <br />
</StructureSection>
</StructureSection>
 +
==References==
 +
<references />
 +
[[Category:Topic Page]]

Current revision

Structure of uracil glycosylase inhibitor (green) complex with uracil DNA glycosylase (cyan) (PDB entry 1uug)

Drag the structure with the mouse to rotate

References

  1. ↑ Acharya N, Kumar P, Varshney U. Complexes of the uracil-DNA glycosylase inhibitor protein, Ugi, with Mycobacterium smegmatis and Mycobacterium tuberculosis uracil-DNA glycosylases. Microbiology. 2003 Jul;149(Pt 7):1647-58. PMID:12855717 doi:http://dx.doi.org/10.1099/mic.0.26228-0
  2. ↑ Putnam CD, Shroyer MJ, Lundquist AJ, Mol CD, Arvai AS, Mosbaugh DW, Tainer JA. Protein mimicry of DNA from crystal structures of the uracil-DNA glycosylase inhibitor protein and its complex with Escherichia coli uracil-DNA glycosylase. J Mol Biol. 1999 Mar 26;287(2):331-46. PMID:10080896 doi:10.1006/jmbi.1999.2605

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Jaime Prilusky

Retrieved from "http://52.214.119.220/wiki/index.php/Uracil_glycosylase_inhibitor"
Personal tools