5hi9
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the full-length TRPV2 channel by cryo-electron microscopy== | |
| + | <SX load='5hi9' size='340' side='right' viewer='molstar' caption='[[5hi9]], [[Resolution|resolution]] 4.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5hi9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HI9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HI9 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.4Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hi9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hi9 OCA], [https://pdbe.org/5hi9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hi9 RCSB], [https://www.ebi.ac.uk/pdbsum/5hi9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hi9 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TRPV2_RAT TRPV2_RAT] Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH (By similarity).<ref>PMID:10201375</ref> <ref>PMID:15249591</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Ion channels 3D structures|Ion channels 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Cohen | + | </SX> |
| - | [[Category: Jiansen | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Rattus norvegicus]] |
| - | [[Category: | + | [[Category: Cohen MR]] |
| - | [[Category: | + | [[Category: Huynh KW]] |
| - | [[Category: | + | [[Category: Jiansen J]] |
| + | [[Category: Lodowski DT]] | ||
| + | [[Category: Moiseenkova-Bell VY]] | ||
| + | [[Category: Samanta A]] | ||
| + | [[Category: Zhou ZH]] | ||
Current revision
Structure of the full-length TRPV2 channel by cryo-electron microscopy
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