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5ie1
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5ie1 is ON HOLD Authors: John B. Jordan, Douglas A. Whittington, Michael D. Bartberger, E. Allen Sickmier, Kui Chen, Yuan Cheng , Ted Judd Descript...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of BACE1 in complex with 3-(2-amino-6-(o-tolyl)quinolin-3-yl)-N-(3,3-dimethylbutyl)propanamide== | |
| + | <StructureSection load='5ie1' size='340' side='right'caption='[[5ie1]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5ie1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IE1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IE1 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.298Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6BS:3-[2-AMINO-6-(2-METHYLPHENYL)QUINOLIN-3-YL]-N-(3,3-DIMETHYLBUTYL)PROPANAMIDE'>6BS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ie1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ie1 OCA], [https://pdbe.org/5ie1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ie1 RCSB], [https://www.ebi.ac.uk/pdbsum/5ie1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ie1 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Beta secretase 3D structures|Beta secretase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bartberger MD]] | ||
| + | [[Category: Chen K]] | ||
| + | [[Category: Cheng Y]] | ||
| + | [[Category: Jordan JB]] | ||
| + | [[Category: Judd T]] | ||
| + | [[Category: Sickmier EA]] | ||
| + | [[Category: Whittington DA]] | ||
Current revision
Crystal structure of BACE1 in complex with 3-(2-amino-6-(o-tolyl)quinolin-3-yl)-N-(3,3-dimethylbutyl)propanamide
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Categories: Homo sapiens | Large Structures | Bartberger MD | Chen K | Cheng Y | Jordan JB | Judd T | Sickmier EA | Whittington DA
