5ayg

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==Crystal Structure of the Human ROR gamma Ligand Binding Domain With 3g==
==Crystal Structure of the Human ROR gamma Ligand Binding Domain With 3g==
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<StructureSection load='5ayg' size='340' side='right' caption='[[5ayg]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='5ayg' size='340' side='right'caption='[[5ayg]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ayg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AYG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AYG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ayg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AYG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AYG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4LQ:3-[5-(2-CYCLOHEXYLETHYL)-4-ETHYL-1,2,4-TRIAZOL-3-YL]-N-NAPHTHALEN-1-YL-PROPANAMIDE'>4LQ</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ayg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ayg OCA], [http://pdbe.org/5ayg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ayg RCSB], [http://www.ebi.ac.uk/pdbsum/5ayg PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4LQ:3-[5-(2-CYCLOHEXYLETHYL)-4-ETHYL-1,2,4-TRIAZOL-3-YL]-N-NAPHTHALEN-1-YL-PROPANAMIDE'>4LQ</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ayg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ayg OCA], [https://pdbe.org/5ayg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ayg RCSB], [https://www.ebi.ac.uk/pdbsum/5ayg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ayg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN]] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
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[https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Adachi, T]]
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[[Category: Homo sapiens]]
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[[Category: Doi, S]]
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[[Category: Large Structures]]
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[[Category: Hirata, K]]
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[[Category: Adachi T]]
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[[Category: Kamada, M]]
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[[Category: Doi S]]
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[[Category: Kikuwaka, M]]
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[[Category: Hirata K]]
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[[Category: Murase, K]]
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[[Category: Kamada M]]
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[[Category: Noguchi, M]]
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[[Category: Kikuwaka M]]
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[[Category: Nomura, A]]
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[[Category: Murase K]]
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[[Category: Complex]]
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[[Category: Noguchi M]]
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[[Category: Dna binding protein-inhibitor complex]]
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[[Category: Nomura A]]
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[[Category: Inhibitor]]
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[[Category: Nuclear receptor]]
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Current revision

Crystal Structure of the Human ROR gamma Ligand Binding Domain With 3g

PDB ID 5ayg

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