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5btf

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==Crystal structure of a topoisomerase II complex==
==Crystal structure of a topoisomerase II complex==
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<StructureSection load='5btf' size='340' side='right' caption='[[5btf]], [[Resolution|resolution]] 2.61&Aring;' scene=''>
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<StructureSection load='5btf' size='340' side='right'caption='[[5btf]], [[Resolution|resolution]] 2.61&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5btf]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BTF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BTF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5btf]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BTF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BTF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GFN:1-CYCLOPROPYL-6-FLUORO-8-METHOXY-7-[(3S)-3-METHYLPIPERAZIN-1-YL]-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC+ACID'>GFN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.61&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GFN:1-CYCLOPROPYL-6-FLUORO-8-METHOXY-7-[(3S)-3-METHYLPIPERAZIN-1-YL]-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC+ACID'>GFN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5btf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5btf OCA], [https://pdbe.org/5btf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5btf RCSB], [https://www.ebi.ac.uk/pdbsum/5btf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5btf ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5btf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5btf OCA], [http://pdbe.org/5btf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5btf RCSB], [http://www.ebi.ac.uk/pdbsum/5btf PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GYRA_MYCTU GYRA_MYCTU]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings. [[http://www.uniprot.org/uniprot/GYRB_MYCTU GYRB_MYCTU]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity).
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[https://www.uniprot.org/uniprot/GYRA_MYCTU GYRA_MYCTU] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5btf" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5btf" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Gyrase 3D Structures|Gyrase 3D Structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Berger, J M]]
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[[Category: Large Structures]]
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[[Category: Blower, T R]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Kerns, R J]]
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[[Category: Synthetic construct]]
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[[Category: Williamson, B H]]
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[[Category: Berger JM]]
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[[Category: Isomerase-dna complex]]
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[[Category: Blower TR]]
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[[Category: Protein-dna complex]]
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[[Category: Kerns RJ]]
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[[Category: Topoisomerase ii]]
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[[Category: Williamson BH]]

Current revision

Crystal structure of a topoisomerase II complex

PDB ID 5btf

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