This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5btd

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:29, 27 September 2023) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
==Crystal structure of a topoisomerase II complex==
==Crystal structure of a topoisomerase II complex==
-
<StructureSection load='5btd' size='340' side='right' caption='[[5btd]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+
<StructureSection load='5btd' size='340' side='right'caption='[[5btd]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5btd]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BTD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BTD FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5btd]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BTD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BTD FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GFN:1-CYCLOPROPYL-6-FLUORO-8-METHOXY-7-[(3S)-3-METHYLPIPERAZIN-1-YL]-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC+ACID'>GFN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.497&#8491;</td></tr>
-
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GFN:1-CYCLOPROPYL-6-FLUORO-8-METHOXY-7-[(3S)-3-METHYLPIPERAZIN-1-YL]-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC+ACID'>GFN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5btd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5btd OCA], [https://pdbe.org/5btd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5btd RCSB], [https://www.ebi.ac.uk/pdbsum/5btd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5btd ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5btd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5btd OCA], [http://pdbe.org/5btd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5btd RCSB], [http://www.ebi.ac.uk/pdbsum/5btd PDBsum]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/GYRA_MYCTU GYRA_MYCTU]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings. [[http://www.uniprot.org/uniprot/GYRB_MYCTU GYRB_MYCTU]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity).
+
[https://www.uniprot.org/uniprot/GYRA_MYCTU GYRA_MYCTU] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 20: Line 19:
</div>
</div>
<div class="pdbe-citations 5btd" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5btd" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Gyrase 3D Structures|Gyrase 3D Structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Berger, J M]]
+
[[Category: Large Structures]]
-
[[Category: Blower, T R]]
+
[[Category: Mycobacterium tuberculosis H37Rv]]
-
[[Category: Kerns, R J]]
+
[[Category: Synthetic construct]]
-
[[Category: Williamson, B H]]
+
[[Category: Berger JM]]
-
[[Category: Isomerase-dna complex]]
+
[[Category: Blower TR]]
-
[[Category: Protein-dna complex]]
+
[[Category: Kerns RJ]]
-
[[Category: Topoisomerase ii]]
+
[[Category: Williamson BH]]

Current revision

Crystal structure of a topoisomerase II complex

PDB ID 5btd

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5btd"
Personal tools