This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5b24

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (15:56, 8 November 2023) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
==The crystal structure of the nucleosome containing cyclobutane pyrimidine dimer==
==The crystal structure of the nucleosome containing cyclobutane pyrimidine dimer==
-
<StructureSection load='5b24' size='340' side='right' caption='[[5b24]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
+
<StructureSection load='5b24' size='340' side='right'caption='[[5b24]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5b24]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B24 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5B24 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5b24]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B24 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5B24 FirstGlance]. <br>
-
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TTD:CIS-SYN+CYCLOBUTANE+THYMINE+DIMER'>TTD</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5b24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b24 OCA], [http://pdbe.org/5b24 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5b24 RCSB], [http://www.ebi.ac.uk/pdbsum/5b24 PDBsum]</span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TTD:CIS-SYN+CYCLOBUTANE+THYMINE+DIMER'>TTD</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5b24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b24 OCA], [https://pdbe.org/5b24 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5b24 RCSB], [https://www.ebi.ac.uk/pdbsum/5b24 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5b24 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>
+
[https://www.uniprot.org/uniprot/H31_HUMAN H31_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 18: Line 19:
</div>
</div>
<div class="pdbe-citations 5b24" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5b24" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Histone 3D structures|Histone 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Horikoshi, N]]
+
[[Category: Homo sapiens]]
-
[[Category: Kagawa, W]]
+
[[Category: Large Structures]]
-
[[Category: Kurumizaka, H]]
+
[[Category: Horikoshi N]]
-
[[Category: Osakabe, A]]
+
[[Category: Kagawa W]]
-
[[Category: Tachiwana, H]]
+
[[Category: Kurumizaka H]]
-
[[Category: Cpd]]
+
[[Category: Osakabe A]]
-
[[Category: Nucleosome]]
+
[[Category: Tachiwana H]]
-
[[Category: Photolesion]]
+
-
[[Category: Structural protein-dna complex]]
+

Current revision

The crystal structure of the nucleosome containing cyclobutane pyrimidine dimer

PDB ID 5b24

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5b24"
Personal tools