1gp7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (00:01, 21 November 2024) (edit) (undo)
 
(16 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1gp7.gif|left|200px]]
 
-
{{Structure
+
==Acidic Phospholipase A2 from venom of Ophiophagus Hannah==
-
|PDB= 1gp7 |SIZE=350|CAPTION= <scene name='initialview01'>1gp7</scene>, resolution 2.6&Aring;
+
<StructureSection load='1gp7' size='340' side='right'caption='[[1gp7]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-
|SITE= <scene name='pdbsite=CAA:Ca+Binding+Site+For+Chain+C'>CAA</scene>
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
+
<table><tr><td colspan='2'>[[1gp7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Ophiophagus_hannah Ophiophagus hannah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GP7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GP7 FirstGlance]. <br>
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-
|GENE=
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-
|DOMAIN=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gp7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gp7 OCA], [https://pdbe.org/1gp7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gp7 RCSB], [https://www.ebi.ac.uk/pdbsum/1gp7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gp7 ProSAT]</span></td></tr>
-
|RELATEDENTRY=
+
</table>
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gp7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gp7 OCA], [http://www.ebi.ac.uk/pdbsum/1gp7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gp7 RCSB]</span>
+
== Function ==
-
}}
+
[https://www.uniprot.org/uniprot/PA2A1_OPHHA PA2A1_OPHHA] Snake venom phospholipase A2 (PLA2) that may exhibit cardiotoxicity, myotoxicity, antiplatelet activity, and edema-inducing activity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:9028866</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gp/1gp7_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gp7 ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The crystal structure of an acidic phospholipase A(2) from Ophiophagus hannah (king cobra) has been determined by molecular replacement at 2.6-A resolution to a crystallographic R factor of 20.5% (R(free)=23.3%) with reasonable stereochemistry. The venom enzyme contains an unusual "pancreatic loop." The conformation of the loop is well defined and different from those in pancreas PLA(2), showing its structural variability. This analysis provides the first structure of a PLA(2)-type cardiotoxin. The sites related to the cardiotoxic and myotoxic activities are explored and the oligomer observed in the crystalline state is described.
-
'''ACIDIC PHOSPHOLIPASE A2 FROM VENOM OF OPHIOPHAGUS HANNAH'''
+
Structure of a cardiotoxic phospholipase A(2) from Ophiophagus hannah with the "pancreatic loop".,Zhang HL, Xu SJ, Wang QY, Song SY, Shu YY, Lin ZJ J Struct Biol. 2002 Jun;138(3):207-15. PMID:12217659<ref>PMID:12217659</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 1gp7" style="background-color:#fffaf0;"></div>
-
==Overview==
+
==See Also==
-
The crystal structure of an acidic phospholipase A(2) from Ophiophagus hannah (king cobra) has been determined by molecular replacement at 2.6-A resolution to a crystallographic R factor of 20.5% (R(free)=23.3%) with reasonable stereochemistry. The venom enzyme contains an unusual "pancreatic loop." The conformation of the loop is well defined and different from those in pancreas PLA(2), showing its structural variability. This analysis provides the first structure of a PLA(2)-type cardiotoxin. The sites related to the cardiotoxic and myotoxic activities are explored and the oligomer observed in the crystalline state is described.
+
*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
1GP7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ophiophagus_hannah Ophiophagus hannah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GP7 OCA].
+
__TOC__
-
 
+
</StructureSection>
-
==Reference==
+
[[Category: Large Structures]]
-
Structure of a cardiotoxic phospholipase A(2) from Ophiophagus hannah with the "pancreatic loop"., Zhang HL, Xu SJ, Wang QY, Song SY, Shu YY, Lin ZJ, J Struct Biol. 2002 Jun;138(3):207-15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12217659 12217659]
+
[[Category: Ophiophagus hannah]]
[[Category: Ophiophagus hannah]]
-
[[Category: Phospholipase A(2)]]
+
[[Category: Lin Z]]
-
[[Category: Single protein]]
+
[[Category: Zhang H]]
-
[[Category: Lin, Z.]]
+
-
[[Category: Zhang, H.]]
+
-
[[Category: calcium]]
+
-
[[Category: cardiotoxic activity]]
+
-
[[Category: crystal structure]]
+
-
[[Category: hydrolase]]
+
-
[[Category: king cobra]]
+
-
[[Category: lipid degradation]]
+
-
[[Category: myotoxic activity]]
+
-
[[Category: pancreatic loop]]
+
-
[[Category: phospholipase a2]]
+
-
[[Category: snake venom]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:48:36 2008''
+

Current revision

Acidic Phospholipase A2 from venom of Ophiophagus Hannah

PDB ID 1gp7

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1gp7"
Personal tools