This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Galactose-binding lectin
From Proteopedia
(Difference between revisions)
| (15 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | <StructureSection load=' | + | <StructureSection load='' size='450' side='right' caption='Structure of peanut galactose-binding lectin tetramer complex with β-D-galactose, α-D-glucose, Ca+2 (green) and Mn+2 (purple) ions (PDB entry [[1v6i]])' scene='57/572274/Cv/1'> |
| - | + | ||
== Function == | == Function == | ||
| Line 11: | Line 11: | ||
== Structural highlights == | == Structural highlights == | ||
| - | The carbohydrate ligand binds to 3 loops<ref>PMID:14747696</ref>. | + | The carbohydrate ligand binds to 3 loops<ref>PMID:14747696</ref>. <scene name='57/572274/Cv/6'>β-D-galactose/α-D-glucose binding site</scene> in peanut galactose-binding lectin (PDB entry [[1v6i]]). |
| - | </StructureSection> | + | |
| + | <scene name='57/572274/Cv/7'>Ca coordination site</scene>. | ||
| + | |||
| + | <scene name='57/572274/Cv/8'>Mn coordination site</scene>. Water molecules shown as red spheres. | ||
| + | </StructureSection> | ||
== 3D structures of galactose-binding lectin == | == 3D structures of galactose-binding lectin == | ||
| Line 28: | Line 32: | ||
**[[2dv9]], [[2dvd]] – GBL + β-D-galactose <br /> | **[[2dv9]], [[2dvd]] – GBL + β-D-galactose <br /> | ||
**[[1rir]] – GBL + porphyrin derivative <br /> | **[[1rir]] – GBL + porphyrin derivative <br /> | ||
| + | **[[6v95]], [[6vav]], [[6vaw]], [[6vc3]], [[6vc4]], [[6vgf]] – GBL + galactopyranose derivative <br /> | ||
*''Peanut GBL ternary complex'' | *''Peanut GBL ternary complex'' | ||
| Line 44: | Line 49: | ||
**[[1l7l]], [[1uoj]] – GBL <br /> | **[[1l7l]], [[1uoj]] – GBL <br /> | ||
| + | **[[4cp9]], [[4cpb]], [[7z62]], [[7z63]] – GBL + galactoside <br /> | ||
| + | **[[7fio]], [[7fjh]] – GBL + inhibitor<br /> | ||
*''PaGBL binary complex'' | *''PaGBL binary complex'' | ||
| Line 49: | Line 56: | ||
**[[2wyf]] – GBL + methyl-β-galactose <br /> | **[[2wyf]] – GBL + methyl-β-galactose <br /> | ||
**[[4ljh]] – GBL + β-D-galactose <br /> | **[[4ljh]] – GBL + β-D-galactose <br /> | ||
| - | **[[3zyf]], [[4a6s]] – GBL + galactopyranose derivative<br /> | + | **[[3zyf]], [[4a6s]], [[4yw6]], [[5mih]] – GBL + galactopyranose derivative<br /> |
| + | **[[4ywa]] – GBL + triazole derivative <br /> | ||
| + | **[[6yo3]], [[6yoh]] – GBL + oxidanyl derivative <br /> | ||
*''PaGBL ternary complex'' | *''PaGBL ternary complex'' | ||
**[[3zyh]] – GBL + galactopyranose derivative + gal-lys-pro-leu <br /> | **[[3zyh]] – GBL + galactopyranose derivative + gal-lys-pro-leu <br /> | ||
| + | **[[4yw7]] – GBL + galactopyranose derivative + triazole derivative <br /> | ||
**[[3zyb]] – GBL + β-D-galactose + gal-lys-pro-leu<br /> | **[[3zyb]] – GBL + β-D-galactose + gal-lys-pro-leu<br /> | ||
**[[4lk6]] – GBL + β-D-galactose + chlorophenol red<br /> | **[[4lk6]] – GBL + β-D-galactose + chlorophenol red<br /> | ||
| Line 72: | Line 82: | ||
**[[2ds0]] – LtGBL C terminal (mutant) + sialyllactose <br /> | **[[2ds0]] – LtGBL C terminal (mutant) + sialyllactose <br /> | ||
**[[2zqo]] – LtGBL C terminal + GalNac <br /> | **[[2zqo]] – LtGBL C terminal + GalNac <br /> | ||
| + | |||
| + | *Other GBL | ||
| + | |||
| + | **[[5x4a]], [[3wmp]], [[3wmq]] – GBL residues 47-140 + polysaccharide – ''Sinularia lochmodes'' <br /> | ||
| + | **[[2zqn]] – eGBL C-terminal + lactose – earthworm<br /> | ||
| + | **[[2zqo]] – eGBL C-terminal + GalNac<br /> | ||
| + | **[[6yf6]] – GBL C-terminal + fucoside derivative – ''Enterobacter cloacae''<br /> | ||
| + | **[[5vbk]], [[6bfm]] – GBL - mussell<br /> | ||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
| |||||||||||
3D structures of galactose-binding lectin
Updated on 07-March-2023
References
- ↑ Natchiar SK, Srinivas O, Mitra N, Surolia A, Jayaraman N, Vijayan M. Structural studies on peanut lectin complexed with disaccharides involving different linkages: further insights into the structure and interactions of the lectin. Acta Crystallogr D Biol Crystallogr. 2006 Nov;62(Pt 11):1413-21. Epub 2006, Oct 18. PMID:17057347 doi:10.1107/S0907444906035712
- ↑ Kundhavai Natchiar S, Arockia Jeyaprakash A, Ramya TN, Thomas CJ, Suguna K, Surolia A, Vijayan M. Structural plasticity of peanut lectin: an X-ray analysis involving variation in pH, ligand binding and crystal structure. Acta Crystallogr D Biol Crystallogr. 2004 Feb;60(Pt 2):211-9. Epub 2004, Jan 23. PMID:14747696 doi:http://dx.doi.org/10.1107/S090744490302849X
