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5ejc

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==Crystal structural of the TSC1-TBC1D7 complex==
==Crystal structural of the TSC1-TBC1D7 complex==
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<StructureSection load='5ejc' size='340' side='right' caption='[[5ejc]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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<StructureSection load='5ejc' size='340' side='right'caption='[[5ejc]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ejc]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EJC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ejc]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EJC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EJC FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ejc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ejc OCA], [http://pdbe.org/5ejc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ejc RCSB], [http://www.ebi.ac.uk/pdbsum/5ejc PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ejc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ejc OCA], [https://pdbe.org/5ejc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ejc RCSB], [https://www.ebi.ac.uk/pdbsum/5ejc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ejc ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
 
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[[http://www.uniprot.org/uniprot/TSC1_HUMAN TSC1_HUMAN]] Lymphangioleiomyomatosis;Tuberous sclerosis;Isolated focal cortical dysplasia type IIb. The disease is caused by mutations affecting the gene represented in this entry. The disease may be caused by mutations affecting the gene represented in this entry.
 
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TBCD7_HUMAN TBCD7_HUMAN]] Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question.<ref>PMID:22795129</ref> [[http://www.uniprot.org/uniprot/TSC1_HUMAN TSC1_HUMAN]] In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling.<ref>PMID:12271141</ref> <ref>PMID:15340059</ref>
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[https://www.uniprot.org/uniprot/TBCD7_HUMAN TBCD7_HUMAN] Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question.<ref>PMID:22795129</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Gong, W]]
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[[Category: Homo sapiens]]
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[[Category: Qin, J]]
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[[Category: Large Structures]]
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[[Category: Wang, Z]]
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[[Category: Gong W]]
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[[Category: Xu, W]]
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[[Category: Qin J]]
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[[Category: Signaling protein]]
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[[Category: Wang Z]]
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[[Category: Tbc1d7]]
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[[Category: Xu W]]
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[[Category: Tsc1]]
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Current revision

Crystal structural of the TSC1-TBC1D7 complex

PDB ID 5ejc

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